Literature DB >> 3000834

Physiological and molecular correlates of age-related changes in the human beta-adrenergic receptor system.

R D Feldman.   

Abstract

Aging decreases hormone responsiveness in several receptor systems. In this article I consider both physiological and biochemical studies supporting the hypothesis that beta-adrenergic receptor responsiveness is reduced with aging in humans. Reduced chronotropic and vasodilator responses to the beta-receptor agonists isoproterenol and metaproterenol have been demonstrated. In human leukocytes a reduction in adenylate cyclase (EC 4.6.1.1) activity occurs with aging. More recently it has been suggested that this reduction in beta-adrenergic responsiveness with aging may be caused by an uncoupling of the beta receptor from the catalytic component.

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Year:  1986        PMID： 3000834

Source DB:  PubMed          Journal:  Fed Proc        ISSN： 0014-9446


  6 in total

1.  Age-related changes in effects of insulin-like growth factor I on human osteoblast-like cells.

Authors:  P Y D'avis; C R Frazier; J R Shapiro; N S Fedarko
Journal:  Biochem J       Date:  1997-06-15       Impact factor: 3.857

2.  Low sodium diet corrects the defect in lymphocyte beta-adrenergic responsiveness in hypertensive subjects.

Authors:  R D Feldman; W J Lawton; W L McArdle
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

3.  Intravenous esmolol is well tolerated in elderly patients with heart failure in the early phase of non-ST elevation myocardial infarction.

Authors:  Michael Koutouzis; Savvas Nikolidakis; Anestis Grigoriadis; Dimitrios Koutsogeorgis; Zenon S Kyriakides
Journal:  Drugs Aging       Date:  2006       Impact factor: 3.923

4.  Cardiac muscarinic receptors decrease with age. In vitro and in vivo studies.

Authors:  O E Brodde; U Konschak; K Becker; F Rüter; U Poller; J Jakubetz; J Radke; H R Zerkowski
Journal:  J Clin Invest       Date:  1998-01-15       Impact factor: 14.808

5.  Age-related changes in human oestrogen receptor alpha function and levels in osteoblasts.

Authors:  M A Ankrom; J A Patterson; P Y d'Avis; U K Vetter; M R Blackman; P D Sponseller; M Tayback; P G Robey; J R Shapiro; N S Fedarko
Journal:  Biochem J       Date:  1998-08-01       Impact factor: 3.857

6.  Effect of age on response to treatment in adult patients with severe persistent asthma.

Authors:  Ebrahim Razi; Gholam Abbass Moosavi; Armin Razi
Journal:  Tanaffos       Date:  2012
  6 in total

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