Literature DB >> 3000806

Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619.

K F Chung, T W Evans, P D Graf, J A Nadel.   

Abstract

We studied the effect of a thromboxane A2-mimetic, U46619, on the contractile responses of canine bronchial smooth muscle to cholinergic stimulation in vitro. U46619 (3 X 10(-10) M), at a concentration that did not cause contraction, enhanced the effect of electrical field stimulation at all frequencies; histamine (10(-7) M) and prostaglandin F2 alpha (10(-7) M) did not. U46619 (3 X 10(-10) M) did not affect methacholine-induced contractions. U46619 may therefore increase the prejunctional release of acetylcholine.

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Year:  1985        PMID： 3000806     DOI： 10.1016/0014-2999(85)90012-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

Review 1.  Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques.

Authors:  K F Chung; I M Adcock
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2.  The involvement of central cholinergic system in the pressor effect of intracerebroventricularly injected U-46619, a thromboxane A2 analog, in conscious normotensive rats.

Authors:  Murat Yalcin; Sinan Cavun; M Sertac Yilmaz; Vahide Savci
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-08-26       Impact factor: 3.000

3.  The mechanism of LTE4-induced histamine hyperresponsiveness in guinea-pig tracheal and human bronchial smooth muscle, in vitro.

Authors:  C A Jacques; B W Spur; M Johnson; T H Lee
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 4.  Role of inflammation in the hyperreactivity of the airways in asthma.

Authors:  K F Chung
Journal:  Thorax       Date:  1986-09       Impact factor: 9.139

5.  Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.

Authors:  B D'Agostino; C Advenier; M Falciani; L Gallelli; G Marrocco; E Piegari; A Filippelli; F Rossi
Journal:  Br J Pharmacol       Date:  2001-12       Impact factor: 8.739

6.  Inhibition by endothelin-1 of cholinergic nerve-mediated acetylcholine release and contraction in sheep isolated trachea.

Authors:  P J Henry; A Shen; F Mitchelson; R G Goldie
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

7.  Potentiation by endothelin-1 of cholinergic nerve-mediated contractions in mouse trachea via activation of ETB receptors.

Authors:  P J Henry; R G Goldie
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

8.  Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.

Authors:  P M Paciorek; I S Cowlrick; R S Perkins; J C Taylor; G F Wilkinson; J F Waterfall
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

9.  Bradykinin-induced airflow obstruction and airway plasma exudation: effects of drugs that inhibit acetylcholine, thromboxane A2 or leukotrienes.

Authors:  I Kawikova; H Arakawa; C G Löfdahl; B E Skoogh; J Lötvall
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739
  9 in total

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