| Literature DB >> 30007642 |
Stefany Guimarães Sousa1, Lorena Almeida Oliveira2, Diva de Aguiar Magalhães1, Tarcisio Vieira de Brito1, Jalles Arruda Batista1, Cynthia Maria Carvalho Pereira1, Mariana de Souza Costa3, José Carlos Raposo Mazulo3, Marcelo de Carvalho Filgueiras3, Daniel Fernando Pereira Vasconselos4, Durcilene Alves da Silva5, Francisco Clark Nogueira Barros6, Venícios G Sombra2, Ana Lúcia Ponte Freitas6, Regina Célia Monteiro de Paula2, Judith Pessoa de Andrade Feitosa2, André Luiz Dos Reis Barbosa7.
Abstract
Polysaccharides extracted from plants are very promising molecules in the field of pharmacotherapy. Knowing this, the aim of this study was to extract, characterize and evaluate the action of the polysaccharide of Morinda citrifolia Linn (Noni-PLS) in biological models of inflammatory processes. The characterization tests shown that sample refers to a heteropolysaccharide composed mainly of homogalacturonan and rhamnogalacturonan. This polysaccharide at dose of 10 mg/kg, when tested in our models of inflammation, showed significant activity in reducing carrageenan-induced paw oedema as well as all mediators edemas. This polysaccharide was able to inhibit the migration of leukocytes to the site of inflammation, and still reduced inflammatory nociception tests. This results, allows us to conclude that the polysaccharide extracted from Morinda citrifolia linn has anti-inflammatory potential since it reversed inflammatory parameters such as edema, leukocyte migration and nociception.Entities:
Keywords: Inflammation; Morinda citrifolia linn; Paw oedema; Polysaccharide
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Year: 2018 PMID： 30007642 DOI： 10.1016/j.carbpol.2018.06.042
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381