| Literature DB >> 30007005 |
Jürgen Brück1, Ivana Glocova1, Julia Geisel1, Christina Kellerer1, Martin Röcken1, Kamran Ghoreschi1.
Abstract
Dimethyl fumarate (DMF) promotes an IL-17Alow IFN-γlow IL-4+ CD4+ T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17Alow IFN-γlow IL-4+ CD4+ T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4+ T cells requires an early in vivo recall.Entities:
Keywords: Dimethyl fumarate; EAE; Immunotherapy; T cell vaccine; Th17 cells
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Year: 2018 PMID： 30007005 DOI： 10.1002/eji.201747435
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532