| Literature DB >> 3000690 |
Abstract
The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 mg/ml for chlorhexidine. The implications of these findings in relation to the comparison of the effects of drugs on sperm motility and the development of new contraceptive agents are discussed.Entities:
Keywords: Alcohols; Clinical Research; Contraception; Contraceptive Agents; Economic Factors; Evaluation; Family Planning; Ingredients And Chemicals; Nonoxynol; Organic Chemicals; Reproduction; Research And Development; Research Methodology; Sperm Immobilizing Agents; Sperm Transport; Spermicidal Contraceptive Agents; Technology
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Year: 1985 PMID： 3000690 DOI： 10.1016/0010-7824(85)90108-8
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375