Massimo Antonelli1, Craig M Coopersmith2. 1. Department of Intensive Care Medicine, Anesthesiology and Emergency Medicine, Fondazione Policlicnico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy. massimo.antonelli@unicatt.it. 2. Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, USA.