Literature DB >> 30006713

Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse.

Mercedes Giralt1,2, Amalia Molinero1,2, Juan Hidalgo3,4.   

Abstract

Experimental autoimmune encephalomyelitis (EAE) is one of the most popular animal models of multiple sclerosis (MS). There are a number of EAE models, being actively induced EAE in strains such as C57Bl/6 mice very robust and reproducible. We herewith present details of the materials and methods for active EAE. Mice are immunized with an emulsion of myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55) + complete Freund's adjuvant (supplemented with Mycobacterium tuberculosis), and treated with Bordetella pertussis toxin, to induce EAE. Sham-EAE mice are immunized with bovine serum albumin instead of MOG35-55.

Entities:  

Keywords:  EAE; Experimental autoimmune encephalomyelitis; MOG35–55; Multiple sclerosis; Myelin oligodendrocyte glycoprotein

Mesh：

Substances：

Year:  2018        PMID： 30006713     DOI： 10.1007/978-1-4939-7862-5_17

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  8 in total

1.  Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner.

Authors:  Paula Sanchis; Olaya Fernández-Gayol; Gemma Comes; Anna Escrig; Mercedes Giralt; Richard D Palmiter; Juan Hidalgo
Journal:  Cells       Date:  2020-01-31       Impact factor: 6.600

2.  Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis.

Authors:  Xiaojun Liu; Jinyun Ma; Guiqing Ding; Qianyi Gong; Yuanhua Wang; Hua Yu; Xiaodong Cheng
Journal:  Oxid Med Cell Longev       Date:  2021-12-24       Impact factor: 6.543

Review 3.  TNFα in MS and Its Animal Models: Implications for Chronic Pain in the Disease.

Authors:  Aislinn D Maguire; John R Bethea; Bradley J Kerr
Journal:  Front Neurol       Date:  2021-12-06       Impact factor: 4.003

4.  Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II.

Authors:  Lili Tang; Ge Li; Yang Zheng; Chunmei Hou; Yang Gao; Ying Hao; Zhenfang Gao; Rongliang Mo; Yuxiang Li; Beifen Shen; Renxi Wang; Zhiding Wang; Gencheng Han
Journal:  Front Immunol       Date:  2022-01-13       Impact factor: 7.561

Review 5.  Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis.

Authors:  Zheng Zha; Sisi Liu; Yijiang Liu; Chen Li; Lei Wang
Journal:  Antioxidants (Basel)       Date:  2022-07-29

6.  SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.

Authors:  Patrick O'Connell; Maja K Blake; Sarah Godbehere; Andrea Amalfitano; Yasser A Aldhamen
Journal:  J Neuroinflammation       Date:  2022-10-03       Impact factor: 9.587

7.  Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes.

Authors:  Thibault Harmand; Liyan Y Smeding; Novalia Pishesha; Weiyi Ma; Leif S Ludwig; Robine Janssen; Ashraful Islam; Yushu J Xie; Tao Fang; Nicholas McCaul; William Pinney; Harun R Sugito; Martin A Rossotti; Gualberto Gonzalez-Sapienza; Hidde L Ploegh
Journal:  Nat Biomed Eng       Date:  2021-06-14       Impact factor: 25.671

8.  Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.

Authors:  Shihono Teruya; Yukihiro Hiramatsu; Keiji Nakamura; Aya Fukui-Miyazaki; Kentaro Tsukamoto; Noriko Shinoda; Daisuke Motooka; Shota Nakamura; Keisuke Ishigaki; Naoaki Shinzawa; Takashi Nishida; Fuminori Sugihara; Yusuke Maeda; Yasuhiko Horiguchi
Journal:  mBio       Date:  2020-03-24       Impact factor: 7.867
  8 in total

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