Yo Sasaki1. 1. Department of Genetics, Washington University in St. Louis, Couch Biomedical Research Building, 4515 McKinley Ave., Saint Louis, MO, 63110, United States.
Abstract
Cellular metabolism maintains the life of cells, allowing energy production required for building cellular constituents and maintaining homeostasis under constantly changing external environments. Neuronal cells maintain their structure and function for the entire life of organisms and the loss of neurons, with limited neurogenesis in adults, directly causes loss of complexity in the neuronal networks. The nervous system organizes the neurons by placing cell bodies containing nuclei of similar types of neurons in discrete regions. Accordingly, axons must travel great distances to connect different types of neurons and peripheral organs. The enormous surface area of neurons makes them high-energy demanding to keep their membrane potential. Distal axon survival is dependent on axonal transport that is another energy demanding process. All of these factors make metabolic stress a potential risk factor for neuronal death and neuronal degeneration often associated with metabolic diseases. This review discusses recent findings on metabolic dysregulations under neuronal degeneration and pathways protecting neurons in these conditions.
Cellular metabolism maintains the life of cells, allowing energy production required for building cellular constituents and maintaining homeostasis under constantly changing external environments. Neuronal cells maintain their structure and function for the entire life of organisms and the loss of neurons, with limited neurogenesis in adults, directly causes loss of complexity in the neuronal networks. The nervous system organizes the neurons by placing cell bodies containing nuclei of similar types of neurons in discrete regions. Accordingly, axons must travel great distances to connect different types of neurons and peripheral organs. The enormous surface area of neurons makes them high-energy demanding to keep their membrane potential. Distal axon survival is dependent on axonal transport that is another energy demanding process. All of these factors make metabolic stress a potential risk factor for n class="Disease">neuronal death and neuronal degeneration often associated with metabolic diseases. This review discusses recent findings on metabolic dysregulations under neuronal degeneration and pathways protecting neurons in these conditions.
Authors: Mohtashem Samsam; Weiqian Mi; Carsten Wessig; Jürgen Zielasek; Klaus V Toyka; Michael P Coleman; Rudolf Martini Journal: J Neurosci Date: 2003-04-01 Impact factor: 6.167
Authors: Krish Chandrasekaran; Muragundla Anjaneyulu; Joungil Choi; Pranith Kumar; Mohammad Salimian; Cheng-Ying Ho; James W Russell Journal: Int Rev Neurobiol Date: 2019-06-08 Impact factor: 3.230
Authors: Krish Chandrasekaran; Neda Najimi; Avinash R Sagi; Sushuma Yarlagadda; Mohammad Salimian; Muhammed Ikbal Arvas; Ahmad F Hedayat; Yanni Kevas; Anand Kadakia; James W Russell Journal: Int J Mol Sci Date: 2022-04-28 Impact factor: 6.208
Authors: Krish Chandrasekaran; Mohammad Salimian; Sruthi R Konduru; Joungil Choi; Pranith Kumar; Aaron Long; Nina Klimova; Cheng-Ying Ho; Tibor Kristian; James W Russell Journal: Brain Date: 2019-12-01 Impact factor: 13.501
Authors: Krish Chandrasekaran; Joungil Choi; Muhammed Ikbal Arvas; Mohammad Salimian; Sujal Singh; Su Xu; Rao P Gullapalli; Tibor Kristian; James William Russell Journal: Int J Mol Sci Date: 2020-05-26 Impact factor: 5.923