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Literature DB >> 30006146

Nitro-fatty acid formation and metabolism.

Gregory J Buchan¹, Gustavo Bonacci², Marco Fazzari³, Sonia R Salvatore¹, Stacy Gelhaus Wendell⁴.

Abstract

Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.

Entities: Chemical Disease Gene Species

Keywords: Diet; Metabolism; Nitration; Nitric oxide; Nitro-conjugated linoleic acid; Nitro-fatty acid; Nitrogen dioxide

Mesh：

Substances：

Year: 2018 PMID： 30006146 PMCID： PMC6241218 DOI： 10.1016/j.niox.2018.07.003

Source DB: PubMed Journal: Nitric Oxide ISSN： 1089-8603 Impact factor: 4.427

51 in total

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Journal: Lipids Date: 2001-05 Impact factor: 1.880

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Journal: Arch Pharm Res Date: 2009-08-29 Impact factor: 4.946

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Authors: A A Spector
Journal: J Lipid Res Date: 1975-05 Impact factor: 5.922

4. Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells.

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Journal: J Lipid Res Date: 2011-01-17 Impact factor: 5.922

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Authors: Ernst E van Faassen; Soheyl Bahrami; Martin Feelisch; Neil Hogg; Malte Kelm; Daniel B Kim-Shapiro; Andrey V Kozlov; Haitao Li; Jon O Lundberg; Ron Mason; Hans Nohl; Tienush Rassaf; Alexandre Samouilov; Anny Slama-Schwok; Sruti Shiva; Anatoly F Vanin; Eddie Weitzberg; Jay Zweier; Mark T Gladwin
Journal: Med Res Rev Date: 2009-09 Impact factor: 12.944

6. Nitrated fatty acids: synthesis and measurement.

Authors: Steven R Woodcock; Gustavo Bonacci; Stacy L Gelhaus; Francisco J Schopfer
Journal: Free Radic Biol Med Date: 2012-11-29 Impact factor: 7.376

7. Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.

Authors: D A Wink; J F Darbyshire; R W Nims; J E Saavedra; P C Ford
Journal: Chem Res Toxicol Date: 1993 Jan-Feb Impact factor: 3.739

Review 8. Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids.

Authors: Meghan Delmastro-Greenwood; Bruce A Freeman; Stacy Gelhaus Wendell
Journal: Annu Rev Physiol Date: 2013-10-16 Impact factor: 19.318

9. Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans.

Authors: Sonia R Salvatore; Dario A Vitturi; Marco Fazzari; Diane K Jorkasky; Francisco J Schopfer
Journal: Sci Rep Date: 2017-01-05 Impact factor: 4.379

10. Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships.

Authors: Nicholas K H Khoo; Lihua Li; Sonia R Salvatore; Francisco J Schopfer; Bruce A Freeman
Journal: Sci Rep Date: 2018-02-02 Impact factor: 4.379

9 in total

Review 1. Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology.

Authors: Francisco J Schopfer; Nicholas K H Khoo
Journal: Trends Endocrinol Metab Date: 2019-06-10 Impact factor: 12.015

2. Nitrated fatty acids: from diet to disease.

Authors: Nicholas K H Khoo; Francisco J Schopfer
Journal: Curr Opin Physiol Date: 2019-04-22

3. Redox properties and human serum albumin binding of nitro-oleic acid.

Authors: Martina Zatloukalova; Milos Mojovic; Aleksandra Pavicevic; Martin Kabelac; Bruce A Freeman; Michaela Pekarova; Jan Vacek
Journal: Redox Biol Date: 2019-05-08 Impact factor: 11.799

4. Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.

Authors: Beatriz Sánchez-Calvo; Adriana Cassina; Mauricio Mastrogiovanni; Mariela Santos; Emiliano Trias; Eric E Kelley; Homero Rubbo; Andrés Trostchansky
Journal: J Nutr Biochem Date: 2021-04-07 Impact factor: 6.117

5. Advancing Target Identification of Nitrated Phospholipids in Biological Systems by HCD Specific Fragmentation Fingerprinting in Orbitrap Platforms.

Authors: Bruna Neves; Sofia Duarte; Pedro Domingues; Dolores Pérez-Sala; Maria Manuel Oliveira; Maria do Rosário Domingues; Tânia Melo
Journal: Molecules Date: 2020-05-01 Impact factor: 4.411