Donald L Chi1, Margaret Rosenfeld2, Lloyd Mancl3, Whasun O Chung3, Richard B Presland4, Elise Sarvas5, Marilynn Rothen3, Alaa Alkhateeb3, Sharon McNamara2, Alan Genatossio2, Isabel Virella-Lowell6, Carlos Milla7, JoAnna Scott8. 1. University of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA. Electronic address: dchi@uw.edu. 2. Seattle Children's Hospital, Cystic Fibrosis Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA. 3. University of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA. 4. University of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA; University of Washington, Department of Medicine, Division of Dermatology, Box 356524, Seattle, WA 98195, USA. 5. University of Minnesota, School of Dentistry, Department of Pediatric Dentistry, 515 Delaware Street SE, Minneapolis, MN 55455, USA. 6. University of Alabama - Birmingham, Division of Pediatric Pulmonology and Sleep Medicine, 1600 7th Ave S, Birmingham, AL 35233, USA. 7. Stanford University Medical School, 770 Welch Rd, Ste. 350, Palo Alto, CA 94304, USA. 8. University of Missouri - Kansas City, School of Dentistry, Department of Dental Public, Health and Behavioral Science, 650 E. 25th St., Kansas City, MO 64108, USA.
Abstract
BACKGROUND: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. METHODS: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. RESULTS: Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. CONCLUSIONS: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.
BACKGROUND: The literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls. METHODS: Prospective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF. RESULTS:Children ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF. CONCLUSIONS: Younger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.
Authors: John J Warren; Karin Weber-Gasparoni; Teresa A Marshall; David R Drake; Farideh Dehkordi-Vakil; Deborah V Dawson; Katie M Tharp Journal: Community Dent Oral Epidemiol Date: 2008-11-12 Impact factor: 3.383