| Literature DB >> 3000572 |
P E Postmus, T J Hirschler-Schulte, L De Leij, S Poppema, J E Elema, E T Edens, G Mesander, H J Sluiter, T H The.
Abstract
A monoclonal antibody (MOC-1) directed against an antigen present in small cell lung cancer (SCLC) was used for diagnostic purposes. After screening of biopsy specimens of lung tumors, MOC-1 was found to react with SCLC (n = 10) and adenocarcinoma of the lung (4 of 9 cases). Except for a few cells in a poorly differentiated tumor, the reaction with squamous cell cancer was negative (n = 6). Staining with MOC-1 by an immunoperoxidase technique on imprints of biopsy specimens procured by rigid bronchoscopy was found to be a reliable and rapid method for diagnosing SCLC (16 of 17 positive). All cytologically proven bone marrow and pleural metastases of SCLC were found by staining on a cytospin preparation with MOC-1. Moreover, in three cytologically negative cases, MOC-1-positive cells were detected.Entities:
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Year: 1986 PMID： 3000572 DOI： 10.1002/1097-0142(19860101)57:1<60::aid-cncr2820570113>3.0.co;2-l
Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860