Satoru Ikemoto1, Shin-Ichiro Hamano2, Susumu Yokota3, Reiko Koichihara4, Yuko Hirata5, Ryuki Matsuura6. 1. Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan; Department of Pediatrics, Jikei University School of Medicine, 3-19-18Nishi-shinbashi, Minato-ku, Tokyo 105-8471, Japan. Electronic address: ike-satoru@hotmail.co.jp. 2. Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan; Department for Child Health and Human Development, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan. 3. Department for Physiological Laboratory, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan. 4. Department for Child Health and Human Development, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan. 5. Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan; Department of Pediatrics, Jikei University School of Medicine, 3-19-18Nishi-shinbashi, Minato-ku, Tokyo 105-8471, Japan. 6. Division of Neurology, Saitama Children's Medical Center, 2-1Shin-toshin, Chuou-ku, Saitama-city, Saitama 330-8777, Japan.
Abstract
OBJECTIVE: To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS. METHODS: Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized. We determined the IED-ripple co-occurrence rate, performed time frequency analysis, and calculated the asymmetry index (AI). RESULTS: The IEDs-ripple co-occurrence rate increased in the SBS compared to the non-SBS period. Time frequency analysis showed higher high-frequency activity rate and peak power in the SBS than in the non-SBS period. The AI was lower in ABECTS than BECTS, both in the non-SBS and SBS periods. CONCLUSIONS: Ripples were enhanced in the SBS period of ABECTS, and bilaterally synchronized both in the non-SBS and SBS periods, whereas ripples in BECTS were localized unilaterally. SIGNIFICANCE: Bilaterally synchronized ripples in the non-SBS period of ABECTS may distinguish ABECTS from BECTS in the non-SBS period of IEDs, and may be helpful for early detection of progressive neurophysiological regression leading to early intervention.
OBJECTIVE: To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS. METHODS: Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized. We determined the IED-ripple co-occurrence rate, performed time frequency analysis, and calculated the asymmetry index (AI). RESULTS: The IEDs-ripple co-occurrence rate increased in the SBS compared to the non-SBS period. Time frequency analysis showed higher high-frequency activity rate and peak power in the SBS than in the non-SBS period. The AI was lower in ABECTS than BECTS, both in the non-SBS and SBS periods. CONCLUSIONS: Ripples were enhanced in the SBS period of ABECTS, and bilaterally synchronized both in the non-SBS and SBS periods, whereas ripples in BECTS were localized unilaterally. SIGNIFICANCE: Bilaterally synchronized ripples in the non-SBS period of ABECTS may distinguish ABECTS from BECTS in the non-SBS period of IEDs, and may be helpful for early detection of progressive neurophysiological regression leading to early intervention.
Authors: Li Yang; Quanping Su; Na Xu; Liyun Xu; Juan Zhao; Chao Fan; Yufen Li; Baomin Li Journal: Medicine (Baltimore) Date: 2020-10-30 Impact factor: 1.817