PURPOSE OF REVIEW: It has been demonstrated that within one pain entity, patients may report highly heterogenic sensory signs and symptoms. Although mechanism might differ fundamentally between those patients, yet the treatment recommendations are uniform throughout all phenotypes. Therefore, the introduction of new stratification tools could pave the way to an individualized pain treatment. RECENT FINDINGS: In the past, retrospective stratifications of patients successfully identified responders to certain pharmacological treatments. This indicated predictive validity and reliability of this classification tool in those patient subgroups. Further on, these observations have been confirmed in prospective studies. SUMMARY: This review focusses on recent achievements in neuropathic pain and suggests a promising implementation of an individualized pharmacological therapy in the future.
PURPOSE OF REVIEW: It has been demonstrated that within one pain entity, patients may report highly heterogenic sensory signs and symptoms. Although mechanism might differ fundamentally between those patients, yet the treatment recommendations are uniform throughout all phenotypes. Therefore, the introduction of new stratification tools could pave the way to an individualized pain treatment. RECENT FINDINGS: In the past, retrospective stratifications of patients successfully identified responders to certain pharmacological treatments. This indicated predictive validity and reliability of this classification tool in those patient subgroups. Further on, these observations have been confirmed in prospective studies. SUMMARY: This review focusses on recent achievements in neuropathic pain and suggests a promising implementation of an individualized pharmacological therapy in the future.
Authors: Janne Gierthmühlen; Johann Böhmer; Nadine Attal; Didier Bouhassira; Rainer Freynhagen; Maija Haanpää; Per Hansson; Troels Staehelin Jensen; Jeffrey Kennedy; Christoph Maier; Andrew S C Rice; Juliane Sachau; Märta Segerdahl; Sören Sindrup; Thomas Tölle; Rolf-Detlef Treede; Lise Ventzel; Jan Vollert; Ralf Baron Journal: Pain Date: 2021-09-23 Impact factor: 7.926
Authors: Hélène L M Ruel; Ryota Watanabe; Marina C Evangelista; Guy Beauchamp; Jean-Philippe Auger; Mariela Segura; Paulo V Steagall Journal: PLoS One Date: 2020-11-30 Impact factor: 3.240
Authors: Karen D Davis; Nima Aghaeepour; Andrew H Ahn; Martin S Angst; David Borsook; Ashley Brenton; Michael E Burczynski; Christopher Crean; Robert Edwards; Brice Gaudilliere; Georgene W Hergenroeder; Michael J Iadarola; Smriti Iyengar; Yunyun Jiang; Jiang-Ti Kong; Sean Mackey; Carl Y Saab; Christine N Sang; Joachim Scholz; Marta Segerdahl; Irene Tracey; Christin Veasley; Jing Wang; Tor D Wager; Ajay D Wasan; Mary Ann Pelleymounter Journal: Nat Rev Neurol Date: 2020-06-15 Impact factor: 42.937