| Literature DB >> 30003917 |
Isaac Yaw Massey1, Fei Yang2, Zhen Ding3, Shu Yang4, Jian Guo5, Clara Tezi6, Muwaffak Al-Osman7, Robert Boukem Kamegni8, Weiming Zeng9.
Abstract
Microcystins (MCs) pollution has quickly risen in infamy and has become a major problem to public health worldwide. MCs are a group of monocyclic hepatotoxic peptides, which are produced by some bloom-forming cyanobacteria in water. More than 100 different MCs variants posing a great threat to animals and humans due to their potential carcinogenicity have been reported. To reduce MCs risks, the World Health Organization has set a provisional guideline of 1 μg/L MCs in human's drinking water. This paper provides an overview of exposure routes of MCs into the human system and health effects on different organs after MCs exposure including the liver, intestine, brain, kidney, lung, heart and reproductive system. In addition, some evidences on human poisoning and deaths associated with MCs exposure are presented. Finally, in order to protect human life against the health threats posed by MCs, this paper also suggests some directions for future research that can advance MCs control and minimize human exposure to MCs.Entities:
Keywords: Cyanobacteria; Health; Microcystins (MCs); Organs; Toxicity
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Year: 2018 PMID： 30003917 DOI： 10.1016/j.toxicon.2018.07.010
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033