Literature DB >> 3000367

Activation by gamma interferon of human macrophage capability to produce toxic oxygen molecules is accompanied by decreased Km of the superoxide-generating NADPH oxidase.

M A Cassatella, V Della Bianca, G Berton, F Rossi.   

Abstract

Capability to release superoxide anion in response to phorbol myristate acetate by intact cells has been compared with Kinetic properties of NADPH oxidase by lysates of human monocytes and monocyte-derived macrophages. Maturation of monocytes in vitro is accompanied by substantial decrease of the capability to release superoxide anion in response to phorbol myristate acetate. Exposure of mature macrophages to recombinant interferon gamma enhances respiratory burst activity up to 3-4 fold. Modifications of NADPH oxidase accompany changes in the ability to release superoxide anion. The affinity of the oxidase for its substrate is higher in monocytes and gamma interferon treated macrophages, while Vmax is not changed.

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Year:  1985        PMID： 3000367     DOI： 10.1016/0006-291x(85)91893-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease.

Authors:  R A Ezekowitz; S H Orkin; P E Newburger
Journal:  J Clin Invest       Date:  1987-10       Impact factor: 14.808

2.  The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.

Authors:  R M Smith; J A Connor; L M Chen; B M Babior
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

3.  Augmentation of the human monocyte/macrophage chemiluminescence response during short-term exposure to interferon-gamma and tumour necrosis factor-alpha.

Authors:  L M Kumaratilake; A Ferrante; E J Bates; I C Kowanko
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

4.  Changes in respiratory burst activity during human monocyte differentiation in suspension culture.

Authors:  J M Zeller; J Caliendo; T F Lint; D J Nelson
Journal:  Inflammation       Date:  1988-12       Impact factor: 4.092

Review 5.  New perspectives in chronic granulomatous disease.

Authors:  R A Ezekowitz; P E Newburger
Journal:  J Clin Immunol       Date:  1988-11       Impact factor: 8.317

6.  Stimulation of neutrophil respiratory burst and lysosomal enzyme release by human interferon-gamma.

Authors:  I C Kowanko; A Ferrante
Journal:  Immunology       Date:  1987-09       Impact factor: 7.397

7.  The development of cytochrome b-245 in maturing human macrophages.

Authors:  R C Garcia; A R Cross; A W Segal
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

8.  Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils. Attenuation of p47phox and p67phox membrane translocation as the mechanism.

Authors:  W Chao; R G Spragg; R M Smith
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

9.  Generation of superoxide anion by alveolar macrophages in sarcoidosis: evidence for the activation of the oxygen metabolism in patients with high-intensity alveolitis.

Authors:  M A Cassatella; G Berton; C Agostini; R Zambello; L Trentin; A Cipriani; G Semenzato
Journal:  Immunology       Date:  1989-03       Impact factor: 7.397

10.  Tumor necrosis factor and immune interferon synergistically induce cytochrome b-245 heavy-chain gene expression and nicotinamide-adenine dinucleotide phosphate hydrogenase oxidase in human leukemic myeloid cells.

Authors:  M A Cassatella; L Hartman; B Perussia; G Trinchieri
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808
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