Literature DB >> 30003388

NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders.

Chengyan Chu1,2, Yue Gao3, Xiaoyan Lan1, Aline Thomas2, Shen Li4.   

Abstract

The neural cell adhesion molecule (NCAM) plays a pivotal role in the development and maintenance of the nervous system via homophilic (NCAM-NCAM) and heterophilic (NCAM-other molecules) interactions. Many synthetic peptides have been engineered to mimic these interactions and induce NCAM-downstream signaling pathways. Such NCAM mimetics have displayed neuritogenic and neuroprotective properties, as well as synaptic modulation in vitro and in vivo. Furthermore, they have been used successfully in preclinical studies to treat neurological disorders including stroke, traumatic brain injury and Alzheimer's disease. This review focuses on recent progress in the development of NCAM mimetic peptides, in particular, on establishing C3, plannexin, and FGL as therapeutic candidates for neurological disorders.

Entities:  

Keywords:  Bioactive peptides; Fibroblast growth factor receptor; Mimetic peptides; Neural cell adhesion molecule; Neurological disorders

Mesh：

Substances：

Year:  2018        PMID： 30003388     DOI： 10.1007/s11064-018-2594-8

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  71 in total

1.  Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.

Authors:  Vladislav Soroka; Kateryna Kolkova; Jette S Kastrup; Kay Diederichs; Jason Breed; Vladislav V Kiselyov; Flemming M Poulsen; Ingrid K Larsen; Wolfram Welte; Vladimir Berezin; Elisabeth Bock; Christina Kasper
Journal:  Structure       Date:  2003-10       Impact factor: 5.006

Review 2.  Zippers make signals: NCAM-mediated molecular interactions and signal transduction.

Authors:  Peter S Walmod; Kateryna Kolkova; Vladimir Berezin; Elisabeth Bock
Journal:  Neurochem Res       Date:  2004-11       Impact factor: 3.996

3.  Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.

Authors:  B A Cunningham; J J Hemperly; B A Murray; E A Prediger; R Brackenbury; G M Edelman
Journal:  Science       Date:  1987-05-15       Impact factor: 47.728

4.  A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival.

Authors:  Alexandra A Anderson; Claire E Kendal; Mitla Garcia-Maya; Anna V Kenny; Samantha A Morris-Triggs; Teresa Wu; Richard Reynolds; Erhard Hohenester; Jane L Saffell
Journal:  J Neurochem       Date:  2005-08-31       Impact factor: 5.372

5.  A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation.

Authors:  Karine Cambon; Stine M Hansen; Cesar Venero; A Isabel Herrero; Galina Skibo; Vladimir Berezin; Elisabeth Bock; Carmen Sandi
Journal:  J Neurosci       Date:  2004-04-28       Impact factor: 6.167

6.  A peptide motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, NLIKQDDGGSPIRHY, is a binding site for the FGF receptor.

Authors:  Jacob Jacobsen; Vladislav Kiselyov; Elisabeth Bock; Vladimir Berezin
Journal:  Neurochem Res       Date:  2008-03-27       Impact factor: 3.996

Review 7.  The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system.

Authors:  L C Rønn; B P Hartz; E Bock
Journal:  Exp Gerontol       Date:  1998 Nov-Dec       Impact factor: 4.032

8.  The synthetic NCAM-derived peptide, FGL, modulates the transcriptional response to traumatic brain injury.

Authors:  Martin Volmer Pedersen; Rehannah Borup Helweg-Larsen; Finn Cilius Nielsen; Vladimir Berezin; Elisabeth Bock; Milena Penkowa
Journal:  Neurosci Lett       Date:  2008-03-28       Impact factor: 3.046

9.  Distribution of PSA-NCAM in normal, Alzheimer's and Parkinson's disease human brain.

Authors:  Helen C Murray; Victoria F Low; Molly E V Swanson; Birger V Dieriks; Clinton Turner; Richard L M Faull; Maurice A Curtis
Journal:  Neuroscience       Date:  2016-06-07       Impact factor: 3.590

Review 10.  The neural cell adhesion molecule and synaptic plasticity.

Authors:  P Doherty; M S Fazeli; F S Walsh
Journal:  J Neurobiol       Date:  1995-03
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  2 in total

Review 1.  Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions.

Authors:  S Sowparani; P Mahalakshmi; J Pushpa Sweety; Arul Prakash Francis; U M Dhanalekshmi; N Selvasudha
Journal:  Mol Neurobiol       Date:  2022-07-12       Impact factor: 5.682

2.  Decreased Serum NCAM Levels Associated with Cognitive Impairment in Vascular Dementia.

Authors:  Jun Zhao; Wei Lu; Junshan Li; Lei Liu; Xiumin Zhao
Journal:  Dis Markers       Date:  2021-08-31       Impact factor: 3.434
  2 in total

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