Literature DB >> 30002444

Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

Jente van Staalduinen1, David Baker1, Peter Ten Dijke2, Hans van Dam1.   

Abstract

Chemoresistance remains a major complication of cancer treatments. Recent data provide strong evidence that chemoresistance is linked to epithelial-mesenchymal transition (EMT), a latent developmental process, which is re-activated during cancer progression. EMT involves transcriptional reprogramming and is driven by specific EMT transcription factors (EMT-TFs). In this review, we provide support for the idea that EMT-TFs contribute to the development of resistance against cancer therapy and discuss how EMT-TFs might be targeted to advance novel therapeutic approaches to the treatment of cancer.

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Year:  2018        PMID： 30002444     DOI： 10.1038/s41388-018-0378-x

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  195 in total

1.  MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination.

Authors:  Mingyang Lu; Mohit Kumar Jolly; Herbert Levine; José N Onuchic; Eshel Ben-Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-23       Impact factor: 11.205

Review 2.  EMT: 2016.

Authors:  M Angela Nieto; Ruby Yun-Ju Huang; Rebecca A Jackson; Jean Paul Thiery
Journal:  Cell       Date:  2016-06-30       Impact factor: 41.582

Review 3.  Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression.

Authors:  Xin Ye; Robert A Weinberg
Journal:  Trends Cell Biol       Date:  2015-10-01       Impact factor: 20.808

4.  TGF-β-induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops.

Authors:  Jingyu Zhang; Xiao-Jun Tian; Hang Zhang; Yue Teng; Ruoyan Li; Fan Bai; Subbiah Elankumaran; Jianhua Xing
Journal:  Sci Signal       Date:  2014-09-30       Impact factor: 8.192

5.  Coupled reversible and irreversible bistable switches underlying TGFβ-induced epithelial to mesenchymal transition.

Authors:  Xiao-Jun Tian; Hang Zhang; Jianhua Xing
Journal:  Biophys J       Date:  2013-08-20       Impact factor: 4.033

6.  OVOL guides the epithelial-hybrid-mesenchymal transition.

Authors:  Dongya Jia; Mohit Kumar Jolly; Marcelo Boareto; Princy Parsana; Steven M Mooney; Kenneth J Pienta; Herbert Levine; Eshel Ben-Jacob
Journal:  Oncotarget       Date:  2015-06-20

7.  Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy.

Authors:  Bee Luan Khoo; Soo Chin Lee; Prashant Kumar; Tuan Zea Tan; Majid Ebrahimi Warkiani; Samuel G W Ow; Sayantani Nandi; Chwee Teck Lim; Jean Paul Thiery
Journal:  Oncotarget       Date:  2015-06-20

Review 8.  Crosstalk of Oncogenic Signaling Pathways during Epithelial-Mesenchymal Transition.

Authors:  Stephan Lindsey; Sigrid A Langhans
Journal:  Front Oncol       Date:  2014-12-11       Impact factor: 6.244

Review 9.  Epithelial-mesenchymal plasticity in carcinoma metastasis.

Authors:  Jeff H Tsai; Jing Yang
Journal:  Genes Dev       Date:  2013-10-15       Impact factor: 11.361

10.  An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States.

Authors:  Tian Hong; Kazuhide Watanabe; Catherine Ha Ta; Alvaro Villarreal-Ponce; Qing Nie; Xing Dai
Journal:  PLoS Comput Biol       Date:  2015-11-10       Impact factor: 4.475
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  49 in total

Review 1.  TGFβ biology in cancer progression and immunotherapy.

Authors:  Rik Derynck; Shannon J Turley; Rosemary J Akhurst
Journal:  Nat Rev Clin Oncol       Date:  2020-07-24       Impact factor: 66.675

2.  ZNF451 stabilizes TWIST2 through SUMOylation and promotes epithelial-mesenchymal transition.

Authors:  Wang Zeng; Shuchen Gu; Yi Yu; Yili Feng; Mu Xiao; Xin-Hua Feng
Journal:  Am J Cancer Res       Date:  2021-03-01       Impact factor: 6.166

3.  Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.

Authors:  Pablo Tamayo; Thomas R Cech; Franklin W Huang; Josh Lewis Stern; Grace Hibshman; Kevin Hu; Sarah E Ferrara; James C Costello; William Kim
Journal:  Mol Cancer Res       Date:  2020-04-10       Impact factor: 5.852

Review 4.  Broadening horizons: the role of ferroptosis in cancer.

Authors:  Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang
Journal:  Nat Rev Clin Oncol       Date:  2021-01-29       Impact factor: 66.675

Review 5.  Regulation of fibroblast-like synoviocyte transformation by transcription factors in arthritic diseases.

Authors:  Pallavi Bhattaram; Kyle Jones
Journal:  Biochem Pharmacol       Date:  2019-03-13       Impact factor: 5.858

6.  Phosphate Toxicity and Epithelial to Mesenchymal Transition.

Authors:  Eric Lewis; Faith Seltun; Mohammed S Razzaque; Ping He
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

7.  Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT.

Authors:  Hongyang Yi; Guipeng Li; Yongkang Long; Weizheng Liang; Huanhuan Cui; Bin Zhang; Ying Tan; Yunfei Li; Luochen Shen; Daqi Deng; Yisen Tang; Chenyu Mao; Shuye Tian; Yunting Cai; Qionghua Zhu; Yuhui Hu; Wei Chen; Liang Fang
Journal:  Oncogene       Date:  2020-06-13       Impact factor: 9.867

8.  Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axis.

Authors:  Na Yao; Yue Fu; Lie Chen; Zhao Liu; Jing He; Yichao Zhu; Tiansong Xia; Shui Wang
Journal:  Oncogene       Date:  2019-08-23       Impact factor: 9.867

9.  Ellagic Acid Resensitizes Gemcitabine-Resistant Bladder Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition and Gemcitabine Transporters.

Authors:  Ying-Si Wu; Jar-Yi Ho; Cheng-Ping Yu; Chun-Jung Cho; Chia-Lun Wu; Cheng-Shuo Huang; Hong-Wei Gao; Dah-Shyong Yu
Journal:  Cancers (Basel)       Date:  2021-04-22       Impact factor: 6.639

10.  Cultivation of Head and Neck Squamous Cell Carcinoma Cells with Wound Fluid Leads to Cisplatin Resistance via Epithelial-Mesenchymal Transition Induction.

Authors:  Till Jasper Meyer; Manuel Stöth; Helena Moratin; Pascal Ickrath; Marietta Herrmann; Norbert Kleinsasser; Rudolf Hagen; Stephan Hackenberg; Agmal Scherzad
Journal:  Int J Mol Sci       Date:  2021-04-25       Impact factor: 5.923
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