Yuanyuan Mi1, Kewei Ren2, Jiangang Zou3, Yu Bai3, Lifeng Zhang3, Li Zuo3, Atsushi Okada4, Takahiro Yasui4. 1. Department of Urology, Third Affiliated Hospital of Nantong University, 585 Xingyuan Road, Wuxi, China. 2. Department of Orthopedics, the Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin, China. 3. Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University,29 Xinglong Road, Changzhou, China. 4. Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Abstract
BACKGROUND/AIMS: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. METHODS: We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. RESULTS: For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group. However, in stratified analysis by ethnicity, we found that rs11614913 T allele was a risk factor for Asian PCa patients. CONCLUSIONS: Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants. Moreover, miR-146a rs2910164 polymorphism was related to PCa prognosis.
BACKGROUND/AIMS: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which play a significant role in transcriptional and translational regulation. Published data on the association between the miRNA SNPs and prostate cancer (PCa) risk are somewhat inconclusive. METHODS: We performed a meta-analysis of all available studies including 2,227 patients and 2,331 control subjects to evaluate the impact of three common genetic variants of microRNAs in prostate cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to investigate the strength of the association. RESULTS: For miR-499 polymorphism, a significant association was observed between the rs3746444 A>G polymorphism and PCa risk in heterozygote comparison and dominant genetic model, in particular in Asian population subgroup. For miR-146a polymorphism, the rs2910164 CC genotype was associated with decreased PCa risk in Asian population in homozygote comparison. In addition, rs2910164 CC genotype had a weekly higher percentage value in subgroup of Gleason score < 7. Similar results were also indicated in localized prostate cancer in subgroup analysis by tumor stage. For miR-196a2 polymorphism, no association was observed between this variant and PCa risk in the overall group. However, in stratified analysis by ethnicity, we found that rs11614913 T allele was a risk factor for Asian PCa patients. CONCLUSIONS: Polymorphisms of miR-196a2rs11614913, miR-146ars2910164, and miR-499rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants. Moreover, miR-146ars2910164 polymorphism was related to PCa prognosis.
Authors: Tirza Gabrielle Ramos de Mesquita; José do Espírito Santo Junior; Thais Carneiro de Lacerda; Krys Layane Guimarães Duarte Queiroz; Cláudio Marcello da Silveira Júnior; José Pereira de Moura Neto; Lissianne Augusta Matos Gomes; Mara Lúcia Gomes de Souza; Marcus Vinitius de Farias Guerra; Rajendranath Ramasawmy Journal: PLoS Negl Trop Dis Date: 2021-09-20
Authors: Silvia Jiménez-Morales; Juan Carlos Núñez-Enríquez; Jazmín Cruz-Islas; Vilma Carolina Bekker-Méndez; Elva Jiménez-Hernández; Aurora Medina-Sanson; Irma Olarte-Carrillo; Adolfo Martínez-Tovar; Janet Flores-Lujano; Julian Ramírez-Bello; María Luisa Pérez-Saldívar; Jorge Alfonso Martín-Trejo; Héctor Pérez-Lorenzana; Raquel Amador-Sánchez; Felix Gustavo Mora-Ríos; José Gabriel Peñaloza-González; David Aldebarán Duarte-Rodríguez; José Refugio Torres-Nava; Juan Eduardo Flores-Bautista; Rosa Martha Espinosa-Elizondo; Pedro Francisco Román-Zepeda; Luz Victoria Flores-Villegas; Edna Liliana Tamez-Gómez; Víctor Hugo López-García; José Ramón Lara-Ramos; Juana Esther González-Ulivarri; Sofía Irene Martínez-Silva; Gilberto Espinoza-Anrubio; Carolina Almeida-Hernández; Rosario Ramírez-Colorado; Luis Hernández-Mora; Luis Ramiro García-López; Gabriela Adriana Cruz-Ojeda; Arturo Emilio Godoy-Esquivel; Iris Contreras-Hernández; Abraham Medina-Hernández; María Guadalupe López-Caballero; Norma Angélica Hernández-Pineda; Jorge Granados-Kraulles; María Adriana Rodríguez-Vázquez; Delfino Torres-Valle; Carlos Cortés-Reyes; Francisco Medrano-López; Jessica Arleet Pérez-Gómez; Annel Martínez-Ríos; Antonio Aguilar-De-Los-Santos; Berenice Serafin-Díaz; María de Lourdes Gutiérrez-Rivera; Laura Elizabeth Merino-Pasaye; Gilberto Vargas-Alarcón; Minerva Mata-Rocha; Omar Alejandro Sepúlveda-Robles; Haydeé Rosas-Vargas; Alfredo Hidalgo-Miranda; Juan Manuel Mejía-Aranguré Journal: Front Oncol Date: 2021-11-05 Impact factor: 6.244