Kalpana Rose1,2, Hatem Krema2,3, Priya Durairaj3, Wantanee Dangboon3, Yael Chavez3, Susith I Kulasekara4, Christopher Hudson1,2. 1. School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada. 2. Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. 3. Ocular Oncology Service, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada. 4. Department of Ophthalmology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Abstract
PURPOSE: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. METHODS: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control. Both eyes underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography (OCT) and Hyperspectral Retinal Camera, respectively. RESULTS: The average TRBF in the retinopathy eye was significantly lower compared to the fellow eye (33.48 ± 12.73 μl/min versus 50.37 ± 15.26 μl/min; p = 0.013). The arteriolar oxygen saturation (SaO2 ) and venular oxygen saturation (SvO2 ) were higher in the retinopathy eye compared to the fellow eye (101.11 ± 4.26%, versus 94.45 ± 5.79%; p = 0.008) and (62.96 ± 11.05% versus 51.24 ± 6.88%, p = 0.051), respectively. CONCLUSION: The ionizing radiation seems to have an impact on the TRBF, SaO2 and SvO2 , clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy.
PURPOSE: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma. METHODS: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control. Both eyes underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography (OCT) and Hyperspectral Retinal Camera, respectively. RESULTS: The average TRBF in the retinopathy eye was significantly lower compared to the fellow eye (33.48 ± 12.73 μl/min versus 50.37 ± 15.26 μl/min; p = 0.013). The arteriolar oxygen saturation (SaO2 ) and venular oxygen saturation (SvO2 ) were higher in the retinopathy eye compared to the fellow eye (101.11 ± 4.26%, versus 94.45 ± 5.79%; p = 0.008) and (62.96 ± 11.05% versus 51.24 ± 6.88%, p = 0.051), respectively. CONCLUSION: The ionizing radiation seems to have an impact on the TRBF, SaO2 and SvO2 , clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy.
Authors: Konstantin N Loganovsky; Donatella Marazziti; Pavlo A Fedirko; Kostiantyn V Kuts; Katerina Y Antypchuk; Iryna V Perchuk; Tetyana F Babenko; Tetyana K Loganovska; Olena O Kolosynska; George Y Kreinis; Marina V Gresko; Sergii V Masiuk; Federico Mucci; Leonid L Zdorenko; Alessandra Della Vecchia; Natalia A Zdanevich; Natalia A Garkava; Raisa Y Dorichevska; Zlata L Vasilenko; Victor I Kravchenko; Nataliya V Drosdova Journal: Life (Basel) Date: 2020-04-16
Authors: Niels J Brouwer; Marina Marinkovic; Jaco C Bleeker; Mariam El Filali; Einar Stefansson; Gregorius P M Luyten; Martine J Jager Journal: Retina Date: 2020-11 Impact factor: 3.975
Authors: Sophie Lemmens; Jan Van Eijgen; Karel Van Keer; Julie Jacob; Sinéad Moylett; Lies De Groef; Toon Vancraenendonck; Patrick De Boever; Ingeborg Stalmans Journal: Transl Vis Sci Technol Date: 2020-08-05 Impact factor: 3.283