| Literature DB >> 2999542 |
Y Sakurai, H Ohta, T Shimazoe, Y Kataoka, M Fujiwara, S Ueki.
Abstract
The present study was designed to examine the influence of delta 9-tetrahydrocannabinol (THC) on the central dopaminergic system using circling behavior. THC 5 mg/kg i.p. produced ipsilateral circling in rats with unilateral nigral lesion by 6-hydroxy-dopamine. THC-induced ipsilateral circling was completely antagonized by 0.2 mg/kg of haloperidol. These findings suggest that THC may cause a presynaptic stimulation of nigrostriatal dopaminergic neurons.Entities:
Mesh：
Substances：
Year: 1985 PMID： 2999542 DOI： 10.1016/0024-3205(85)90569-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037