Fatemeh Nowroozi1, Simin Dadashzadeh1,2, Hoorieh Soleimanjahi3, Azadeh Haeri1, Soraya Shahhosseini4, Jaber Javidi1, Hesam Karimi3. 1. Department of Pharmaceutics, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14115-6153, Iran. 2. Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran. 3. Department of Virology, Faculty of Medical Sciences Tarbiat Modares University Tehran, 331-14115, Iran. 4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran.
Abstract
AIM: For simultaneous bioimaging and drug delivery via direct intratumoral injection, doxorubicin and Ag2S quantum dots co-loaded multifunctional niosomes were prepared and fully characterized. MATERIALS & METHODS: Various theranostic niosomes were prepared and investigated regarding cytotoxicity, in vivo imaging, drug accumulation in breast cancer tumor and antitumor activity. RESULTS: Niosomes composed of Tween-60, Tween-80 or Span 60 produced strong and more durable detectable fluorescence signals. Despite a higher accumulation of Tween-60 niosomes in tumor, the Span 60 formulation showed the highest antitumor efficacy when compared with the free drug (71.7 and 20.3% inhibition in tumor growth, respectively). CONCLUSION: Direct intratumoral injection of theranostic niosomes with appropriate composition could be a powerful tool for combined multimodal imaging and therapy.
AIM: For simultaneous bioimaging and drug delivery via direct intratumoral injection, doxorubicin and Ag2S quantum dots co-loaded multifunctional niosomes were prepared and fully characterized. MATERIALS & METHODS: Various theranostic niosomes were prepared and investigated regarding cytotoxicity, in vivo imaging, drug accumulation in breast cancer tumor and antitumor activity. RESULTS: Niosomes composed of Tween-60, Tween-80 or Span 60 produced strong and more durable detectable fluorescence signals. Despite a higher accumulation of Tween-60 niosomes in tumor, the Span 60 formulation showed the highest antitumor efficacy when compared with the free drug (71.7 and 20.3% inhibition in tumor growth, respectively). CONCLUSION: Direct intratumoral injection of theranostic niosomes with appropriate composition could be a powerful tool for combined multimodal imaging and therapy.
Entities:
Keywords:
Ag2S quantum dots; HLB; breast cancer; cellular uptake; in vivo imaging; intratumoral injection; niosomes; photoluminescence; surfactant; theranostic
Authors: Martina Di Francesco; Christian Celia; Maria Chiara Cristiano; Nicola d'Avanzo; Barbara Ruozi; Constantin Mircioiu; Donato Cosco; Luisa Di Marzio; Massimo Fresta Journal: ACS Omega Date: 2021-01-22