Literature DB >> 29991400

Can patients afford the cost of treatment for multidrug-resistant tuberculosis in Ethiopia?

R H Berhanu1, K Schnippel2, R Kularatne3, C Firnhaber4, K R Jacobson5, C R Horsburgh6, C K Lippincott7.   

Abstract

SETTING: Ethiopia has a high prevalence of tuberculosis (TB) and is one of the countries with the highest burden of multidrug-resistant TB (MDR-TB).
OBJECTIVE: To understand the costs that patients incur in obtaining diagnosis and treatment for MDR-TB.
DESIGN: In March 2013, interviews were conducted with 169 MDR-TB patients at three hospitals in Ethiopia to identify the cost to patients and the impact on employment and family income.
RESULTS: The average MDR-TB patient incurred a total cost of US$1378, which represented 25 months of a mid-treatment household income of US$54. The impact on the patient's employment and on overall patient and family income was generally catastrophic: 74% of all respondents reported losing their jobs, 66% of patients lost household income, and household income was reduced by 38%. To help cover the costs, 38% of patients sold some type of property, while 7% leased out property and 41% took out loans, any of which could jeopardize their future financial situation even further.
CONCLUSION: Despite services being officially free of charge, most patients incurred catastrophic costs and suffered significant income loss as a result of obtaining diagnosis and treatment for MDR-TB.

Entities:  

Mesh:

Year:  2018        PMID: 29991400      PMCID: PMC6421943          DOI: 10.5588/ijtld.17.0837

Source DB:  PubMed          Journal:  Int J Tuberc Lung Dis        ISSN: 1027-3719            Impact factor:   2.373


  9 in total

1.  Evaluation of the analytical performance of the Xpert MTB/RIF assay.

Authors:  Robert Blakemore; Elizabeth Story; Danica Helb; JoAnn Kop; Padmapriya Banada; Michelle R Owens; Soumitesh Chakravorty; Martin Jones; David Alland
Journal:  J Clin Microbiol       Date:  2010-05-26       Impact factor: 5.948

2.  Rifampin drug resistance tests for tuberculosis: challenging the gold standard.

Authors:  Armand Van Deun; Kya J M Aung; Valentin Bola; Rossin Lebeke; Mohamed Anwar Hossain; Willem Bram de Rijk; Leen Rigouts; Aysel Gumusboga; Gabriela Torrea; Bouke C de Jong
Journal:  J Clin Microbiol       Date:  2013-06-12       Impact factor: 5.948

3.  False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load.

Authors:  Oksana Ocheretina; Erin Byrt; Marie-Marcelle Mabou; Gertrude Royal-Mardi; Yves-Mary Merveille; Vanessa Rouzier; Daniel W Fitzgerald; Jean W Pape
Journal:  Diagn Microbiol Infect Dis       Date:  2016-01-15       Impact factor: 2.803

4.  Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland.

Authors:  Elisabeth Sanchez-Padilla; Matthias Merker; Patrick Beckert; Frauke Jochims; Themba Dlamini; Patricia Kahn; Maryline Bonnet; Stefan Niemann
Journal:  N Engl J Med       Date:  2015-03-19       Impact factor: 91.245

5.  Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis.

Authors:  Syed Beenish Rufai; Parveen Kumar; Amit Singh; Suneel Prajapati; Veena Balooni; Sarman Singh
Journal:  J Clin Microbiol       Date:  2014-03-19       Impact factor: 5.948

6.  Tuberculosis control in South Africa: successes, challenges and recommendations.

Authors:  G J Churchyard; L D Mametja; L Mvusi; N Ndjeka; A C Hesseling; A Reid; S Babatunde; Y Pillay
Journal:  S Afr Med J       Date:  2014-03

Review 7.  Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.

Authors:  Karen R Steingart; Ian Schiller; David J Horne; Madhukar Pai; Catharina C Boehme; Nandini Dendukuri
Journal:  Cochrane Database Syst Rev       Date:  2014-01-21

8.  Mixed Mycobacterium tuberculosis complex infections and false-negative results for rifampin resistance by GeneXpert MTB/RIF are associated with poor clinical outcomes.

Authors:  Nicola M Zetola; Sanghyuk S Shin; Kefentse A Tumedi; Keletso Moeti; Ronald Ncube; Mark Nicol; Ronald G Collman; Jeffrey D Klausner; Chawangwa Modongo
Journal:  J Clin Microbiol       Date:  2014-04-30       Impact factor: 5.948

9.  How should discordance between molecular and growth-based assays for rifampicin resistance be investigated?

Authors:  S Hofmann-Thiel; H Hoffmann; D Hillemann; L Rigouts; A Van Deun; K Kranzer
Journal:  Int J Tuberc Lung Dis       Date:  2017-07-01       Impact factor: 2.373

  9 in total
  2 in total

1.  A systematic review and meta-analysis of the catastrophic costs incurred by tuberculosis patients.

Authors:  Ramy Mohamed Ghazy; Haider M El Saeh; Shaimaa Abdulaziz; Esraa Abdellatif Hammouda; Amira Mohamed Elzorkany; Heba Khidr; Nardine Zarif; Ehab Elrewany; Samar Abd ElHafeez
Journal:  Sci Rep       Date:  2022-01-11       Impact factor: 4.379

2.  Financial burden of HIV and TB among patients in Ethiopia: a cross-sectional survey.

Authors:  Lelisa Fekadu Assebe; Eyerusalem Kebede Negussie; Abdulrahman Jbaily; Mieraf Taddesse Taddesse Tolla; Kjell Arne Johansson
Journal:  BMJ Open       Date:  2020-06-01       Impact factor: 2.692

  2 in total

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