Y Hirsch-Moverman1, J E Mantell2, L Lebelo3, C Wynn4, A C Hesseling5, A A Howard1, S Nachman6, K Frederix3, L B Maama7, W M El-Sadr1. 1. ICAP at Columbia University, Mailman School of Public Health, New York, Department of Epidemiology, Columbia University, New York. 2. HIV Center for Clinical & Behavioral Studies, Division of Gender, Sexuality and Health, New York State Psychiatric Institute and Columbia University, Department of Psychiatry, New York. 3. ICAP at Columbia University, Mailman School of Public Health, New York. 4. Department of Sociomedical Sciences, Columbia University, New York, New York, USA. 5. Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. 6. Pediatric Infectious Diseases, State University of New York Stony Brook, Stony Brook, New York, USA. 7. Lesotho Ministry of Health National Tuberculosis Program, Maseru, Lesotho.
Abstract
BACKGROUND: Shorter-duration regimens for preventing drug-susceptible tuberculosis (TB) have been shown to be safe and efficacious in children, and may improve acceptability, adherence, and treatment completion. While these regimens have been used in children in low TB burden countries, they are not yet widely used in high TB burden countries. SETTING: Five health facilities in one district in Lesotho, a high TB burden country. OBJECTIVE: Assess the preventive treatment preferences of care givers of child TB contacts. DESIGN: Qualitative data were collected using in-depth interviews with 12 care givers whose children completed preventive treatment, and analyzed using grounded theory. FINDINGS: Care givers were interested in being involved in the children's treatment decisions. Pill burden, treatment duration and related frequency of dosing were identified as important factors that influenced preventive treatment preferences among care givers. CONCLUSION: Understanding care giver preferences and involving them in treatment decisions may facilitate efforts to implement successful preventive treatment for TB among children in high TB burden countries.
BACKGROUND: Shorter-duration regimens for preventing drug-susceptible tuberculosis (TB) have been shown to be safe and efficacious in children, and may improve acceptability, adherence, and treatment completion. While these regimens have been used in children in low TB burden countries, they are not yet widely used in high TB burden countries. SETTING: Five health facilities in one district in Lesotho, a high TB burden country. OBJECTIVE: Assess the preventive treatment preferences of care givers of child TB contacts. DESIGN: Qualitative data were collected using in-depth interviews with 12 care givers whose children completed preventive treatment, and analyzed using grounded theory. FINDINGS: Care givers were interested in being involved in the children's treatment decisions. Pill burden, treatment duration and related frequency of dosing were identified as important factors that influenced preventive treatment preferences among care givers. CONCLUSION: Understanding care giver preferences and involving them in treatment decisions may facilitate efforts to implement successful preventive treatment for TB among children in high TB burden countries.
Authors: Dillon T Wademan; Graeme Hoddinott; Susan E Purchase; James A Seddon; Anneke C Hesseling; Anthony J Garcia-Prats; Ria Reis; Lindsey J Reynolds Journal: PLoS One Date: 2022-07-14 Impact factor: 3.752
Authors: Courtney M Yuen; Ana K Millones; Jerome T Galea; Daniela Puma; Judith Jimenez; Leonid Lecca; Mercedes C Becerra; Salmaan Keshavjee Journal: BMC Public Health Date: 2021-01-11 Impact factor: 3.295
Authors: Yael Hirsch-Moverman; Michael Strauss; Gavin George; Anthony Mutiti; Arnold Mafukidze; Siphesihle Shongwe; Gloria Sisi Dube; Wafaa M El Sadr; Joanne E Mantell; Andrea A Howard Journal: BMJ Open Date: 2021-10-22 Impact factor: 3.006