Postoperative Fever Evaluation Following Lumbar Fusion Procedures.

OBJECTIVE: This study aimed to determine the incidence of postoperative fever, the workup conducted for postoperative fever, the rate of subsequent fever-related diagnoses or complications, and the risk factors associated with fever following lumbar fusion.
METHODS: A retrospective review of patients undergoing lumbar fusion was performed. For patients in whom fever (≥38.6°C) was documented, charts were reviewed for any fever workup or diagnosis. Multivariate regression was used to identify independent risk factors for the development of postoperative fever.
RESULTS: A total of 868 patients met the inclusion criteria, of whom 105 exhibited at least 1 episode of fever during hospitalization. The first documentation of fever occurred during the first 24 hours in 43.8% of cases, during postoperative hours 24-48 in 53.3%, and later than 48 hours postoperatively in 2.9%. At least 1 component of a fever workup was conducted in 47 of the 105 patients who had fever, resulting in fever-associated diagnoses in 4 patients prior to discharge. Three patients who had fever during the inpatient stay developed complications after discharge. On multivariate analysis, operations longer than 150 minutes (relative risk [RR], 1.66; p=0.015) and narcotic consumption greater than 85 oral morphine equivalents on postoperative day 0 (RR, 1.53; p=0.038) were independently associated with an increased risk of developing postoperative fever.
CONCLUSION: The results of this study suggest that inpatient fever occurred in roughly 1 in 8 patients following lumbar fusion surgery. In most cases where a fever workup was performed, no cause of fever was detected. Longer operative time and increased early postoperative narcotic use may increase the risk of developing postoperative fever.

INTRODUCTION

Postoperative fever is a common occurrence following both general and orthopedic surgical procedures, with a reported incidence between 10% and 73% [1-5]. Postoperative complications such as urinary tract infection (UTI), sepsis, pneumonia (PNA), surgical site infection (SSI), deep vein thrombosis (DVT), and pulmonary embolism (PE) may result in pyrexia [6-9]. However, not all postoperative fevers are a cause for concern nor do they all necessitate immediate evaluation, as intraoperative tissue damage and inflammation may also result in pyrexia [9-11].

When postoperative fevers do arise, further workup including urinalyses (UA), urine cultures, blood cultures, chest radiographs (chest x-ray, CXR), or sputum cultures are often ordered to determine the etiology of the postoperative fever and to rule out potentially dangerous complications [12]. However, fever workups can be expensive, time consuming, prolong hospitalization, and are often inconclusive [5,13-15]. As such, it is essential for physicians to understand the utility of these tests and at what point they should be ordered.

The necessity of fever evaluation has previously been examined following both general [16-18] and orthopaedic surgeries [12]. However, a large majority of the orthopedic literature has focused on fevers following total joint arthroplasty [2,4,6,8,9,11,12,14,19-21], while fever management following orthopedic spine procedures [22-24] has not been well assessed. In this context, the purpose of this study is to describe the frequency and timing of postoperative fevers, the results of fever workups, and the risk factors for developing postoperative fevers following lumbar fusion procedures.

MATERIALS AND METHODS

Following Institutional Review Board approval (ORA# 14051 301), a prospectively maintained database of consecutive patients undergoing elective lumbar fusion procedures by a single surgeon from 2005–2016 was reviewed. Patients undergoing any level, primary or revision transforaminal (TLIF), posterior (PLIF), anterior (ALIF), or lateral (LLIF) lumbar interbody fusions were eligible for inclusion in the study. Patients undergoing fusion for degenerative or isthmic spondylolisthesis, spinal stenosis, degenerative disc disease, or herniated nucleus pulposus were included. Patients undergoing fusion for infection, fracture, or those in which a concurrent corpectomy was performed were excluded from the analysis. Concurrent corpectomy patients were excluded in order to standardize the patient population to only include those undergoing interbody fusion.

As part of routine protocol, temperature was taken every 4 hours on postoperative inpatients. The first temperature is recorded as soon as the patient arrives into the postanesthesia care unit. For patients in whom any postoperative fever (temperature ≥38.6°C) was documented, both inpatient charts and postoperative outpatient clinic notes were further reviewed for any fever workup, diagnoses that may have potentially resulted in elevated body temperature, and treatment given. Components of a fever workup included UA, urine culture, CXR, blood culture, sputum culture, venous duplex ultrasound, and chest computed tomography (CT). Components of the workup performed were not standardized and depended on the clinical suspicion. Diagnoses that were considered to be complications causing fever included SSI, UTI, PNA, DVT, and PE. Other causes of fever such as atelectasis were also recorded if diagnosed after CXR. However, these were not characterized as complications as they are causes of fever that do not require changes in standard postoperative management. At our institution, barring any associated symptoms, a temperature≥38.6°C within 48 hours after surgery prompts intervention in the form of acetaminophen (if tolerable by the patient), an ice pack wrapped in a towel, and instructions to use the incentive spirometer 10 times per hour. These may be applied individually or in combination.

Results of fever workups were summarized using descriptive statistics, and multivariate Poisson regression with robust error variance was used identify independent risk factors for the development of fever. Potential risk factors investigated included: age of 60 years old or greater, male sex, smoking, a Charlson Comorbidity Index [25] score greater than 1, presence of diabetes mellitus, posterior operative approach, revision fusion procedure, undergoing an operation on greater than 1 level, a body mass index greater than or equal to 30 kg/m2, an operative time greater than or equal to 150 minutes, an estimated blood loss greater than or equal to 100 mL, and narcotic consumption on postoperative day (POD) 0 greater than or equal to 85 oral morphine equivalents (OMEs). Statistical significance was set at p<0.05.

RESULTS

A total of 868 patients undergoing lumbar fusion procedures met inclusion criteria and were included in the analysis (Table 1). A majority of patients underwent procedures that were 1-level procedures (88.3%). Similarly, a majority were posterior-only fusion procedures (77.9%).

Table 1.

Patient characteristics (n=868)

Characteristic	Value
Age (yr)	52.1 ± 13.0
Sex
Female	361 (41.59)
Male	507 (58.41)
Obesity
Nonobese (< 30 kg/m2)	457 (52.65)
Obese (≥ 30 kg/m2)	411 (47.35)
Smoking status
Nonsmoker	573 (77.22)
Smoker	169 (22.78)
Ageless comorbidity burden (CCI)	1.26 ± 1.38
Diabetes mellitus
Not diabetic	784 (90.32)
Diabetic	84 (9.68)
Procedure type
Primary	656 (83.25)
Revision	132 (16.75)
Operative approach
Anterior/lateral	191 (22.06)
Posterior	675 (77.94)
Number of levels
1 Level	760 (88.27)
2 Level	91 (10.57)
3 Level	10 (1.16)
Operative time (min)	142.66 ± 71.13
Estimated blood loss (mL)	77.29 ± 98.35
Length of stay (hr)	60.92 ± 39.63
POD 0 narcotic (OME)	88.53 ± 69.83

Values are presented as mean±standard deviation or number (%).

CCI, Charlson Comorbidity Index; POD, postoperative day; OME, oral morphine equivalent.

A total of 105 patients (12.1%) exhibited at least one episode of fever during their hospital course. Of those who developed fevers, 64 (61.0%) had only one documented fever, 15 (14.3%) had two documented fevers, and 26 (24.7%) had 3 or more documented fevers (Fig. 1). A 43.8% of first-documented fevers occurred during the first 24 hours following surgery, 53.3% during postoperative hours 24–48, and 2.9% following 48 hours (Fig. 2).

Fig. 1.

Number of fevers following lumbar fusion. Of those who developed fevers, 64 (61.0%) had only one documented fever, 15 (14.3%) had 2 documented fevers, and 26 (24.7%) had 3 or more documented fevers.

Fig. 2.

Timing of postoperative fever. A 43.8% of first-documented fevers occurred during the first 24 hours following surgery, 53.3% during postoperative hours 24–48, and 2.9% following 48 hours. All patients diagnosed with a postoperative complication had their first documented fever during the first 48 postoperative hours. PNA, pneumonia; DVT, deep vein thrombosis; UTI, urinary tract infection. *Complication was diagnosed during the inpatient stay.

Table 2 describes risk factors associated with the development of a postoperative fever. Male sex (relative risk [RR], 1.53; p=0.039), revision fusion procedures (RR, 1.63; p=0.031), and operative duration greater than 150 minutes (RR, 1.69; p=0.006) were identified as risk factors for the development of a postoperative fever. On multivariate analysis, operations longer than 150 minutes (RR, 1.70; p=0.009) and narcotic consumption greater than 85 OMEs on POD 0 (RR. 1.56; p=0.027) were independently associated with increased risk of developing postoperative fever (Table 3).

Table 2.

Risk factors for postoperative fever

Variable	No. (%)	RR	95% CI	p-value[†]
Overall	98/861 (11.38)
Age (yr)				0.953
18–59	69/604 (11.42)	Reference	-
≥ 60	29/228 (12.72)	0.99	0.66–0.49
Sex				0.039[*]
Female	31/357 (8.68)	Reference	-
Male	67/504 (13.29)	1.53	1.02–2.29
Obesity				0.215
Nonobese (< 30 kg/m2)	46/455 (10.11)	Reference	-
Obese (≥ 30 kg/m2)	52/406 (12.81)	1.27	0.87–1.84
Current smoker				0.112
No	70/571 (12.26)	Reference	-
Yes	13/168 (7.74)	0.63	0.36–1.11
Ageless CCI				0.827
<2	70/623 (11.24)	Reference	-
≥2	28/238 (11.76)	1.05	0.69–1.58
Diabetes mellitus				0.092
Not diabetic	84/778 (10.8)	Reference	-
Diabetic	14/83 (16.87)	1.56	0.93–2.62
Procedure type				0.031[*]
Primary	67/656 (10.21)	Reference
Revision	22/132 (16.67)	1.63	1.05–2.54
Operative approach				0.547
Anterior/lateral	24/190 (12.63)	Reference	-
Posterior	74/669 (11.06)	0.88	0.57–1.35
Number of operative levels				0.224
Single level	82/753 (10.89)	Reference	-
Multilevel	16/108 (14.81)	1.36	0.83–2.24
Operative duration (min)				0.006[*]
< 150	57/604 (9.44)	Reference	-
≥ 150	41/257 (15.95)	1.69	1.16–2.46
Estimated blood loss (mL)				0.652
< 100	80/688 (11.63)	Reference	-
≥ 100	18/173 (10.4)	0.89	0.55–1.45
Narcotics usage (OME)[‡]				0.066
< 85	48/497 (9.66)	Reference	-
≥ 85	49/357 (13.73)	1.42	0.98–2.07

No. (%), number with fever/total in group (rate of fever).

RR, relative risk; CI, confidence interval; CCI, Charlson Comorbidity Index; OME, oral morphine equivalent; POD, postoperative day.

p<0.05, statistically significance.

p-value determined using Poisson regression with robust error variance.

Average OME consumed on POD 0.

Table 3.

Independent risk factors for postoperative fever

Variable	RR	95% CI	p-value[†]
Narcotics usage[*] (OME)			0.027
< 85 OME	Reference	-
≥ 85 OME	1.56	1.05–2.32
Operative duration (min)			0.009
< 150	Reference	-
≥ 150	1.70	1.14–2.54

RR, relative risk; CI, confidence interval; OME, oral morphine equivalent; POD, postoperative day.

Average OME consumed on POD 0.

p-value calculated using stepwise Poisson regression with robust error variance controlling for age, gender, obesity, smoking status, comorbidity burden, diabetes mellitus, operative approach, procedure type, number of levels fused, operative time, estimated blood loss, average narcotic use on postoperative day 0.

At least one component of a fever workup was conducted in 47 of the 105 patients (44.8%) who had a fever (Fig. 3). Urinalysis was performed in 43 patients (41.0%), urine culture in 33 patients (31.4%), CXR in 25 patients (23.8%), blood cultures in 8 patients (7.6%), duplex ultrasound in 2 patients (1.9%), CT chest in 2 patients (1.9%), and sputum culture in 1 patient (1.0%). Of the 47 patients who received a fever workup, the first workup test was performed on POD 0 for 1 patient (2.1%), POD 1 for 16 patients (34.0%), POD 2 for 20 patients (42.6%), POD 3 in 6 patients (12.8%), and POD 4 or later in 4 patients (8.5%).

Fig. 3.

Postoperative fever workups performed. At least one component of a fever workup was conducted in 47 of the 105 patients (44.8%) who had a fever. Urinalysis (UA) was performed in 43 patients (41.0%), urine culture (UCx) in 33 patients (31.4%), chest x-ray (CXR) in 25 patients (23.8%), blood cultures (BCx) in 8 patients (7.6%), duplex ultrasound in 2 patients (1.9%), CT chest in 2 patients (1.9%), and sputum culture (SCx) in 1 patient (1.0%).

Detailed information on patients who developed postoperative complications is presented in Table 4. Of those with fevers, 4 patients (3.8%) were diagnosed with an inpatient complication following workup (2 PNAs, 2 UTIs; Fig. 2). In these patients, 3 of 4 demonstrated other signs or symptoms that increased suspicion for a complication, including shortness of breath, tachycardia/oxygen desaturations, and dysuria. Additionally, 3 patients (2.9%) who had fevers during the inpatient stay developed complications that were not recognized until after discharge (1 UTI, 1 DVT, and 1 patient with UTI and DVT). Notably, 2 of these 3 patients had each received at least one component of a fever workup as an inpatient that returned negative. The third patient developed a fever 13 hours after surgery that resolved within 10 hours. As such, the patient was presumed to have had a reactive fever, and no workup was performed. Subsequently, the patient developed postoperative urinary retention and consequentially had a length of hospitalization of 103 hours; DVT was diagnosed after discharge. No patient who developed complications had a history of their complication, nor had any medical comorbidities that may have put them at higher risk. Of the patients who received a fever workup without a diagnosed complication, 9 were diagnosed with atelectasis. No SSIs were detected in this series of patients.

Table 4.

Summary of patients who had positive diagnoses

Patient information			Timeline of events		Summary of hospital course
Patient A			Inpatient		POD 2 – Underwent second surgery for persistent dural bleb repair.
	29 Female			POD 0 – Fever 1 (38.9°C), 11 hr
	PNA during stay			POD 4 – Fever 2 (39.2°C), 95 hr	POD 5 – Developed sore throat, shortness of breath, cough. CXR confirmed PNA. Given antibiotics for PNA and empirically for meningitis due to history of CSF leakage.
	Discharge POD 9			POD 4 – WBC max (17.7)
	LOS 219 hr			POD 5 – Fever 6 (40.0°C)[†], 106 hr	POD 7 – Continued to have fevers from POD 4 until POD 7.
		Revision MIS TLIF for pseudomeningocele, pseudarthrosis, 1 level		POD 5 – UA/UCx – Normal
				POD 6 – CXR – PNA[*]
				POD 6 – Duplex – Normal
Patient B			Inpatient		POD 2 – Foley catheter removed
	75 Female			POD 1 – Fever 1 (38.8°C), 24 hr	POD 3 – No reported symptoms but due to fever acquired UA and UCx which was positive for bacteria and leukesterase. Started on antibiotics.
	UTI during stay			POD 3 – Fever 2 (38.8°C)[†], 79 hr
	Discharge POD 4			POD 3 – UA/UCx – UTI[*]	No WBC elevation during stay
	LOS 97 hr			POD 3 – CXR – Atelectasis
	PLF, 1 level			POD 3 – BCX – Normal
Patient C			Inpatient		POD 1 – Had urinary urgency and frequency, no burning or itching.
	73 Female			POD 1 – Fever 1 (39.1°C)[†], 34 hr
	UTI during stay			POD 1 – Fever 2 (38.7°C), 35 hr	POD 3 – Symptoms resolved without treatment but UA demon- strated blood, WBC, and leukesterase. Started on antibiotics.
	Discharge POD 3			POD 1&2 – UA/UCx – Normal
	LOS 78 hr			POD 2 – WBC max (12.0)
	PLF, 1 level			POD 3 – UA – UTI[*]
Patient D			Inpatient		POD 0 – Tachycardia overnight
	29 Male			POD 1 – Fever 1 (38.6°C)[†], 39 hr	POD 1 – Continued tachycardia. Complained of sore throat. Oxygen saturation percent dropped to high 80s overnight
	PNA during stay			POD 1 – UA/UCx – Normal
	Discharge POD 5			POD 1 – CXR, CT – Atelectasis	POD 2 – Second CT demonstrated bibasilar opacities, treated for PNA. Did not complain of chest pain or shortness of breath.
	LOS 120 hr			POD 1 – WBC max (13.1), CRP (63.2)
	MIS TLIF, 1 level			POD 2 – BCX – Normal
				POD 2 – CT – PNA[*]
Patient E			Inpatient		POD 1 – Had urinary retention and received straight catheteriza- tion. Fevers resolved after POD 1.
	53 Male			POD 0 – Fever 1 (38.9°C), 13 hr
	DVT after discharge			POD 1 – Fever 3 (39.2°C)[†], 18 hr	POD 4 – Discharged. No DVT symptoms during stay.
	Discharge POD 4			POD 1 – WBC max (18.3)	POD 18 – Developed pain and swelling in calf. Outside ER diag- nosed DVT with Duplex ultrasound. Started on anticoagulation.
	LOS 103 hr		Outpatient
	MIS TLIF, 1 level			POD 18 – Duplex – DVT[*]
Patient F			Inpatient		POD 1 – Had urinary retention, frequency. Received straight catheterization.
	72 Female			POD 1 – Fever 1 (38.9°C)[†], 16 hr
	DVT, UTI after discharge			POD 2 – WBC max (15.0)	POD 6 –Transfer to rehabilitation facility for further physical therapy, pain management.
	Discharge POD 6			POD 4 – UA/UCx – Normal	POD 7 – Continued urinary frequency. UA demonstrated bacte- ria, leukesterase. Started on antibiotics.
	LOS 142 hr		Rehabilitation facility
	PLF, 1 level			POD 7 – UA/UCx – UTI[*]	POD 19 – Developed leg edema without tenderness. Duplex ultrasound demonstrated right calf DVT.
				POD 19 – Duplex – DVT[*]
			Outpatient		POD 34 – Presented to ER with leg pain, swelling. Duplex ultra- sound demonstrated left calf DVT. Started on anticoagulation.
				POD 34 – Duplex – DVT[*]
Patient G			Inpatient		POD 2 – Developed abdominal distention and urinary retention.
	63 Male			POD 1 – Fever 1 (38.6°C)[†], 35 hr	POD 24 – Called office reporting urinary symptoms. Went to outside ER and diagnosed UTI based on UA.
	UTI after discharge			POD 2 – UA/UCx – Normal
	Discharge POD 3		Outpatient		No WBC elevation during stay
	LOS 79 hr			POD 24 – UA/UCx – UTI[*]
	ALIF, 1 level

POD, postoperative day; LOS, length of stay; POD, postoperative day; MIS TLIF, minimally invasive transforaminal lumbar interbody fusion; PLF, posterior lumbar fusion; ALIF, anterior lumbar interbody fusion; UA, urinalysis; UCx, urine culture; CXR, chest x-ray; CT, computed tomography; BCX, blood culture; PNA, pneumonia; UTI, urinary tract infection; DVT, deep vein thrombosis; ER, emergency room; CSF, cerebrospinal fluid; WBC, white blood count (K/μL); CRP, C-reactive protein (mg/L).

Signifies final diagnosis.

Indicates peak fever.

DISCUSSION

The development of fevers following orthopedic surgery is a frequent event that may be indicative of complications such as infection or thrombosis. However, many instances of postoperative fever are simply postoperative inflammatory reactions or minor pathologies such as atelectasis and not associated with a complication. Although the utility of postoperative fever workup following general surgical, gynecologic, and total joint arthroplasty procedures has previously been reported, the occurrence of fever following orthopedic spine procedures has not been well studied. The present study aimed to investigate the frequency and timing of postoperative fevers and the results of subsequent fever workups following lumbar fusion procedures. This study also describes risk factors associated with postoperative fevers.

The results of the current study suggest that postoperative fever occurs in 12.1% of patients following lumbar fusion procedures. Most patients who exhibit a fever typically have only one instance of fever, which most commonly occurs in the first 48 hours following surgery. It has been reported that postoperative fevers that develop in the first 3 to 4 days following surgery are less likely to be indicative of infectious complications than are fevers that arise on POD 5 or later [26]. Further, one study noted that patients who become febrile on PODs 1 and 2 are less likely to be experiencing an infectious complication than those with fevers occurring on PODs 3 to 5.2 In the majority of patients who developed fever in the present study, no cause was determined. Many were presumed to have atelectasis or other self-limited pathology. Furthermore, the patients who were diagnosed with a complication before or shortly after discharge also had signs or symptoms consistent with an infectious cause. Those who experienced late complications developed symptoms several days after discharge that were likely unrelated to their inpatient fever. Additionally, patients who underwent longer operations and those who consumed a greater amount of narcotic medications on POD 0 were at greater risk of developing postoperative fever.

The incidence of postoperative fever in this study is lower than previous reporting in the spine literature. A previous investigation by Walid et al. [24] reported fever rates following cervical or lumbar procedures of 41.7% and 25.8% using temperature cutoffs of 37.8°C and 38.3°C, respectively. The higher fever rates compared to the present study are likely due to differences in temperature cutoffs as well as increased heterogeneity in the procedures performed. Seo et al. [23] also investigated postoperative fever following a variety of spinal procedures and reported a rate of 13.2% using a cutoff of 37.8°C. However, only fevers that occurred on POD 3 or later and were without an identifiable cause were included, limiting the comparison to the present study.

In a cohort of pediatric patients undergoing posterior spinal fusion predominantly for scoliosis correction, Blumstein et al. [22] reported fever rates of 72% and 9% when using temperature cutoffs of 38°C and 39°C, respectively. The difference in fever rates between Blumstein’s reported values and the results of this study are likely multifactorial. First, deformity correction surgery is longer and requires more tissue destruction than the surgeries performed in the present study. The release of inflammatory cytokines such as interleukin-6 that occurs with tissue damage has been demonstrated to directly correlate with the development of fevers. As such, it is intuitive that a more invasive procedure with increased tissue damage would result in an increased release of cytokines and thus a greater likelihood of postoperative pyrexia [27-29]. Second, pediatric patients experience postoperative fevers more frequently than adults following orthopedic surgery [1]. Lastly, the different temperature thresholds used by Blumstein make it difficult to properly compare the fever incidences.

Many patients with undetermined etiologies on diagnostic fever workup were presumed to have atelectasis or other selflimited pathologies. As a result, only 8.5% of patients who underwent a fever workup had a result indicative of a complication during the inpatient period. Prior studies have reported that fevers occurring after POD 3, lasting longer than 24 hours, reaching a maximum greater than 39°C, or being associated with the presence of a second temperature spike all may be more indicative of an infectious complication [11,21,30,31]. The patients in the present study who developed complications during their inpatient stay either presented with symptoms associated with their eventual diagnosis, had fevers greater than 39°C or other abnormal vital signs, or experienced a second episode of fever. These results suggest that fever workups may not be efficacious in the absence of other signs or symptoms. As the majority of fever work-ups are inconclusive, clinical signs of potential complications should be used as a guide to assist in diagnosis without excessive testing.

The patients who developed complications after discharge were unlikely to be captured by the inpatient workup due to their delayed presentation. Patient E developed a DVT 14 days after discharge, while patient G developed a UTI 21 days after discharge. In both instances their inpatient fevers were likely not related to these complications. Conversely, Patient F was diagnosed with a UTI 1 day after discharge to a rehabilitation facility, despite having negative UA and urine culture prior to discharge. However, this patient was experiencing symptoms consistent with a UTI throughout their stay and was suspected to have an infection, but was not started on or discharged with antibiotic therapy. Of note, the only fever this patient experienced was on POD 1, 16 hours following surgery. This patient also experienced two separate DVTs in different legs on POD 19 and POD 34, significantly after her discharge. The first DVT was not treated with any anticoagulation at that time. Following the second DVT, the patient was put on a long-term anticoagulation regimen. In each of these patients, the complications experienced after discharge were likely unrelated to the fevers they experienced during hospitalization due to the prolonged time between the fever and the diagnosis, emphasizing the limited utility of a fever episode in guiding a diagnostic workup. Importantly, each patient recognized his or her symptoms as an outpatient and sought medical care.

The only risk factors for the development of fever were operations longer than 150 minutes and a total narcotic consumption on POD 0 greater than 85 OMEs (mg). Longer operations have previously been reported as a risk factor for postoperative fever, infection, and other complications following orthopedic surgeries [32-38]. As previously described, the increased length of procedures has been theorized to result in a greater amount of tissue damage and subsequent pyrogen release. Thus, increased procedure time would be a significant risk factor for the development of postoperative fever. In a similar light, the surgical wound is exposed for a greater length of time, increasing the risk of contamination during the operative procedure.

The increased risk of fever with greater narcotic dosage has also been reported in the literature. In a retrospective review of 3,613 patients undergoing total joint arthroplasty, Karam et al. [14] reported that patients who received a multimodal analgesia protocol developed fewer fevers when compared to a cohort who received a narcotic based, patient controlled analgesia (PCA) protocol. This phenomenon is likely due to the anti-pyretic qualities of many of the nonnarcotic analgesics used in a multimodal analgesia protocol. While narcotics have been reported to promote fever, an immunosuppressive effect has also been noted. Beilin et al. [39] reported that fentanyl suppresses natural killer cell cytotoxicity and therefore may weaken immune response. However, the clinical relevance of immunomodulator effects of narcotics remains unclear [40]. As such, narcotic medications should not be limited in an attempt to control pyrexia at the expense of adequate pain control. Rather narcotic dose should be considered as a potential contributor to elevated temperatures when debating whether to pursue a fever workup.

The present study is not without limitations. First, this was a retrospective review of a single surgeon’s operative experience, limiting generalizability. Second, due to the retrospective nature of this study, patient management protocols could not be controlled. Not every patient who developed a fever was worked up for a possible cause and the determination of work-up components was based upon clinical judgement of the treatment team. However, this study provides preliminary data regarding the development of inpatient fever following lumbar fusion procedures that can be utilized to help direct future investigations. Third, more recent patients received a multimodal analgesia protocol, while earlier patients received a PCA pain management strategy, potentially reducing the number of fevers observed in the later patients. While previous studies have suggested that the increased utilization of medications with antipyretic properties in multimodal analgesia protocols can limit fever developement, this has not translated to differences in the identification of complications [14]. Fourth, it is possible that some first fever episodes may have occurred after discharge and therefore were not included in this analysis. However, the primary focus of this study was to describe postoperative fevers as identified on routine inpatient monitoring in order to help guide decision making in this setting. Lastly, a relatively small number of patients developed postoperative fevers, with even fewer developing a complication. This limited the statistical ability to stratify patients with fever by the presence of a complication, analyze risk factors for complications, or determine the elements of a fever workup with the greatest utility in identifying a cause.

CONCLUSION

In summary, approximately 1 in 8 patients develop at least one inpatient fever following lumbar fusion surgery. In a majority of these cases, no cause for fever is detected. However, patients who do have a complication-associated fever will likely present with signs or symptoms consistent with their complication. As such, fever workups following lumbar fusion may be unnecessary unless pursued with the guidance of a postoperative symptom suggesting a potential source. Patients who underwent longer operations and those who consumed a greater amount of narcotic medications on POD 0 were at greater risk of developing postoperative fever. These factors may be considered when defining the risks and benefits of performing a diagnostic workup. Despite the relative rarity of complications following lumbar fusions, it is critical that patients are adequately educated on possible symptoms that may indicate an adverse event and to seek medical care when necessary.