Christian Sandøe Musaeus1, Knut Engedal2, Peter Høgh3,4, Vesna Jelic5,6, Morten Mørup7, Mala Naik8, Anne-Rita Oeksengaard5, Jon Snaedal9, Lars-Olof Wahlund5, Gunhild Waldemar1, Birgitte Bo Andersen1. 1. Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 2. Norwegian National Advisory Unit on Ageing and Health (Ageing and Health), Vestfold Hospital Trust and Oslo University Hospital, Ullevaal, Oslo, Norway. 3. Regional Dementia Research Center, Department of Neurology, Zealand University Hospital, Roskilde, Denmark and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 4. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 5. Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 6. Clinic for Cognitive Disorders, Theme Aging, Karolinska University Hospital-Huddinge, Sweden. 7. Section for Cognitive Systems, DTU Compute, Technical University of Denmark, Lyngby, Denmark. 8. Department of Geriatric Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway. 9. Department of Geriatric Medicine, Landspítali University Hospital, Reykjavik, Iceland.
Abstract
BACKGROUND: Quantitative EEG (qEEG) power could potentially be used as a diagnostic tool for Alzheimer's disease (AD) and may further our understanding of the pathophysiology. However, the early qEEG power changes of AD are not well understood. OBJECTIVE: To investigate the early changes in qEEG power and the possible correlation with memory function and cerebrospinal fluid biomarkers. In addition, whether qEEG power could discriminate between AD, mild cognitive impairment (MCI), and older healthy controls (HC) at the individual level. METHODS: Standard EEGs from 138 HC, 117 MCI, and 117 AD patients were included from six Nordic memory clinics. All EEGs were recorded consecutively before the diagnosis and were not used for the consensus diagnosis. Absolute and relative power was calculated for both eyes closed and open condition. RESULTS: At group level using relative power, we found significant increases globally in the theta band and decreases in high frequency power in the temporal regions for eyes closed for AD and, to a lesser extent, for MCI compared to HC. Relative theta power was significantly correlated with multiple neuropsychological measures and had the largest correlation coefficient with total tau. At the individual level, the classification rate for AD and HC was 72.9% for relative power with eyes closed. CONCLUSION: Our findings suggest that the increase in relative theta power may be the first change in patients with dementia due to AD. At the individual level, we found a moderate classification rate for AD and HC when using EEGs alone.
BACKGROUND: Quantitative EEG (qEEG) power could potentially be used as a diagnostic tool for Alzheimer's disease (AD) and may further our understanding of the pathophysiology. However, the early qEEG power changes of AD are not well understood. OBJECTIVE: To investigate the early changes in qEEG power and the possible correlation with memory function and cerebrospinal fluid biomarkers. In addition, whether qEEG power could discriminate between AD, mild cognitive impairment (MCI), and older healthy controls (HC) at the individual level. METHODS: Standard EEGs from 138 HC, 117 MCI, and 117 ADpatients were included from six Nordic memory clinics. All EEGs were recorded consecutively before the diagnosis and were not used for the consensus diagnosis. Absolute and relative power was calculated for both eyes closed and open condition. RESULTS: At group level using relative power, we found significant increases globally in the theta band and decreases in high frequency power in the temporal regions for eyes closed for AD and, to a lesser extent, for MCI compared to HC. Relative theta power was significantly correlated with multiple neuropsychological measures and had the largest correlation coefficient with total tau. At the individual level, the classification rate for AD and HC was 72.9% for relative power with eyes closed. CONCLUSION: Our findings suggest that the increase in relative theta power may be the first change in patients with dementia due to AD. At the individual level, we found a moderate classification rate for AD and HC when using EEGs alone.
Entities:
Keywords:
Alzheimer’s disease; EEG; dementia; diagnostic; mild cognitive impairment; power
Authors: Fabian Schwimmbeck; Wolfgang Staffen; Christopher Höhn; Fabio Rossini; Nora Renz; Markus Lobendanz; Peter Reichenpfader; Bernhard Iglseder; Ludwig Aigner; Eugen Trinka; Yvonne Höller Journal: Brain Sci Date: 2021-04-27
Authors: Claudio Babiloni; Xianghong Arakaki; Hamed Azami; Karim Bennys; Katarzyna Blinowska; Laura Bonanni; Ana Bujan; Maria C Carrillo; Andrzej Cichocki; Jaisalmer de Frutos-Lucas; Claudio Del Percio; Bruno Dubois; Rebecca Edelmayer; Gary Egan; Stephane Epelbaum; Javier Escudero; Alan Evans; Francesca Farina; Keith Fargo; Alberto Fernández; Raffaele Ferri; Giovanni Frisoni; Harald Hampel; Michael G Harrington; Vesna Jelic; Jaeseung Jeong; Yang Jiang; Maciej Kaminski; Voyko Kavcic; Kerry Kilborn; Sanjeev Kumar; Alice Lam; Lew Lim; Roberta Lizio; David Lopez; Susanna Lopez; Brendan Lucey; Fernando Maestú; William J McGeown; Ian McKeith; Davide Vito Moretti; Flavio Nobili; Giuseppe Noce; John Olichney; Marco Onofrj; Ricardo Osorio; Mario Parra-Rodriguez; Tarek Rajji; Petra Ritter; Andrea Soricelli; Fabrizio Stocchi; Ioannis Tarnanas; John Paul Taylor; Stefan Teipel; Federico Tucci; Mitchell Valdes-Sosa; Pedro Valdes-Sosa; Marco Weiergräber; Gorsev Yener; Bahar Guntekin Journal: Alzheimers Dement Date: 2021-04-15 Impact factor: 16.655
Authors: Kyle D Meeuwsen; Kayleah M Groeneveld; Linda A Walker; Anna M Mennenga; Rachel K Tittle; Elyse K White Journal: Restor Neurol Neurosci Date: 2021 Impact factor: 2.406
Authors: Livia Livint Popa; Mihaela Iancu; Gheorghe Livint; Maria Balea; Constantin Dina; Vitalie Vacaras; Cristian Vladescu; Laura Balanescu; Anca Dana Buzoianu; Stefan Strilciuc; Dafin Muresanu Journal: Neurol Sci Date: 2021-06-25 Impact factor: 3.307