Jihui Lyu1,2, Jingnan Zhang2, Haiyan Mu1, Wenjie Li1, Mei Champ3, Qian Xiong4, Tian Gao5, Lijuan Xie5, Weiye Jin5, Wan Yang5, Mengnan Cui1, Maolong Gao1, Mo Li1. 1. Center for Cognitive Disorders, Beijing Geriatric Hospital, Beijing, China. 2. Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, China. 3. Department of Nursing and Midwifery, University of the West of England, UK. 4. Centre for Ageing Research, Division of Health Research, Faculty of Health and Medicine, Lancaster University, UK. 5. Music Therapy Center, Central Conservatory of Music, Beijing, China.
Abstract
BACKGROUND:Alzheimer's disease (AD) is the most common type of dementia, affecting millions of older people worldwide. However, pharmacological therapies have not achieved desirable clinical efficacy in the past decades. Non-pharmacological therapies have been receiving increased attention to treat dementia in recent years. OBJECTIVE: This study explores the effects of music therapy on cognitive function and mental wellbeing of patients with AD. METHODS: A total number of 298 AD patients with mild, moderate, or severe dementia participated in the study. The participants with each grade of severity were randomly divided into three groups, which were a singing group, a lyric reading group, and a control group. These three groups received different interventions for three months. All participants underwent a series of tests on cognitive functions, neuropsychological symptoms, and activities of daily living at baseline, three months, and six months. RESULTS: The analysis shows that music therapy is more effective for improving verbal fluency and for alleviating the psychiatric symptoms and caregiver distress than lyrics reading in patients with AD. Stratified analysis shows that music therapy is effective for enhancing memory and language ability in patients with mild AD and reducing the psychiatric symptoms and caregiver distress in patients with moderate or severe AD. However, no significant effect was found for activities of daily living in patients with mild, moderate, or severe AD. CONCLUSION: This study suggests that music therapy is effective in enhancing cognitive function and mental wellbeing and can be recommended as an alternative approach to manage AD associated symptoms.
RCT Entities:
BACKGROUND:Alzheimer's disease (AD) is the most common type of dementia, affecting millions of older people worldwide. However, pharmacological therapies have not achieved desirable clinical efficacy in the past decades. Non-pharmacological therapies have been receiving increased attention to treat dementia in recent years. OBJECTIVE: This study explores the effects of music therapy on cognitive function and mental wellbeing of patients with AD. METHODS: A total number of 298 ADpatients with mild, moderate, or severe dementia participated in the study. The participants with each grade of severity were randomly divided into three groups, which were a singing group, a lyric reading group, and a control group. These three groups received different interventions for three months. All participants underwent a series of tests on cognitive functions, neuropsychological symptoms, and activities of daily living at baseline, three months, and six months. RESULTS: The analysis shows that music therapy is more effective for improving verbal fluency and for alleviating the psychiatric symptoms and caregiver distress than lyrics reading in patients with AD. Stratified analysis shows that music therapy is effective for enhancing memory and language ability in patients with mild AD and reducing the psychiatric symptoms and caregiver distress in patients with moderate or severe AD. However, no significant effect was found for activities of daily living in patients with mild, moderate, or severe AD. CONCLUSION: This study suggests that music therapy is effective in enhancing cognitive function and mental wellbeing and can be recommended as an alternative approach to manage AD associated symptoms.
Entities:
Keywords:
Dementia; language; memory; music therapy
Authors: Jennie L Dorris; Stephen Neely; Lauren Terhorst; Helena M VonVille; Juleen Rodakowski Journal: J Am Geriatr Soc Date: 2021-05-18 Impact factor: 7.538