Theodore C Larson1, Wendy Kaye2, Paul Mehta1, D Kevin Horton1. 1. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA. 2. McKing Consulting Corporation, Atlanta, Georgia, USA.
Abstract
BACKGROUND: The International Classification of Disease, 10th Revision (ICD-10) did not include a code specific for Amyotrophic lateral sclerosis (ALS) until 2017. Instead, code G12.2 included both ALS and other motor neuron diseases (MND). Our objective was to determine US mortality rates for ALS exclusively by excluding other MND and progressive supranuclear palsy. METHODS: All mortality data coded as G12.2 under the pre-2017 rubric were obtained for 2011-2014. Deaths without ALS listed in one of the un-coded cause-of-death fields were excluded. ALS death rates per 100,000 persons were age-adjusted to the 2000 US standard population using the direct method. RESULTS: The proportion of excluded records coded G12.2 but not ALS was 0.21, resulting in 24,328 ALS deaths. The overall age-adjusted mortality rate was 1.70 (95% CI 1.68-1.72). The rate among males was 2.09 (95% CI 2.05-2.12) and females was 1.37 (95% CI 1.35-1.40). The overall rate among whites was 1.84, blacks 1.03, and other races 0.70. For both sexes and all races, the rate increased with age and peaked among 75-79 year-olds. Rates tended to be greater in states at higher latitudes. CONCLUSIONS: Previous reports of ALS mortality in the United States showed similar age, sex, and race distributions but with greater age-adjusted mortality rates due to the inclusion of other diseases in the case definition. When using ICD-10 data collected prior to 2017, additional review of multiple-cause of death data is required for the accurate estimation of ALS deaths.
BACKGROUND: The International Classification of Disease, 10th Revision (ICD-10) did not include a code specific for Amyotrophic lateral sclerosis (ALS) until 2017. Instead, code G12.2 included both ALS and other motor neuron diseases (MND). Our objective was to determine US mortality rates for ALS exclusively by excluding other MND and progressive supranuclear palsy. METHODS: All mortality data coded as G12.2 under the pre-2017 rubric were obtained for 2011-2014. Deaths without ALS listed in one of the un-coded cause-of-death fields were excluded. ALS death rates per 100,000 persons were age-adjusted to the 2000 US standard population using the direct method. RESULTS: The proportion of excluded records coded G12.2 but not ALS was 0.21, resulting in 24,328 ALS deaths. The overall age-adjusted mortality rate was 1.70 (95% CI 1.68-1.72). The rate among males was 2.09 (95% CI 2.05-2.12) and females was 1.37 (95% CI 1.35-1.40). The overall rate among whites was 1.84, blacks 1.03, and other races 0.70. For both sexes and all races, the rate increased with age and peaked among 75-79 year-olds. Rates tended to be greater in states at higher latitudes. CONCLUSIONS: Previous reports of ALS mortality in the United States showed similar age, sex, and race distributions but with greater age-adjusted mortality rates due to the inclusion of other diseases in the case definition. When using ICD-10 data collected prior to 2017, additional review of multiple-cause of death data is required for the accurate estimation of ALS deaths.
Authors: Jason M Mehal; Robert C Holman; Lawrence B Schonberger; James J Sejvar Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2013-04-29 Impact factor: 4.092
Authors: Matthew C Kiernan; Steve Vucic; Benjamin C Cheah; Martin R Turner; Andrew Eisen; Orla Hardiman; James R Burrell; Margaret C Zoing Journal: Lancet Date: 2011-02-04 Impact factor: 79.321
Authors: G Logroscino; B J Traynor; O Hardiman; A Chio'; P Couratier; J D Mitchell; R J Swingler; E Beghi Journal: J Neurol Neurosurg Psychiatry Date: 2008-01 Impact factor: 10.154
Authors: Irene van der Steen; Jan-Paul van den Berg; Erik Buskens; Eline Lindeman; Leonard H van den Berg Journal: Amyotroph Lateral Scler Date: 2009-02
Authors: Nathalie Jetté; Hude Quan; Brenda Hemmelgarn; Saskia Drosler; Christina Maass; Lori Moskal; Wansa Paoin; Vijaya Sundararajan; Song Gao; Robert Jakob; Bedihran Ustün; William A Ghali Journal: Med Care Date: 2010-12 Impact factor: 2.983
Authors: Nancy C Wojcik; Elizabeth M Gallagher; Melannie S Alexander; R Jeffrey Lewis Journal: J Occup Environ Med Date: 2022-03-01 Impact factor: 2.306
Authors: Daniel H Daneshvar; Jesse Mez; Michael L Alosco; Zachary H Baucom; Ian Mahar; Christine M Baugh; Jhaqueline P Valle; Jennifer Weuve; Sabrina Paganoni; Robert C Cantu; Ross D Zafonte; Robert A Stern; Thor D Stein; Yorghos Tripodis; Christopher J Nowinski; Ann C McKee Journal: JAMA Netw Open Date: 2021-12-01