Allshine Chen1, Nicolle M Krebs1, Junjia Zhu1, Joshua E Muscat2. 1. Department of Public Health Sciences, Penn State College of Medicine, 500 University Dr., Hershey, PA, 17033, USA. 2. Department of Public Health Sciences, Penn State College of Medicine, 500 University Dr., Hershey, PA, 17033, USA. Electronic address: jmuscat@hmc.psu.edu.
Abstract
BACKGROUND: The nicotine metabolite ratio (NMR) as measured by the ratio of 3'hydroxycotinine to cotinine has been examined in relation to tobacco use patterns including cigarettes per day and quit success to determine its role in nicotine dependence. We examined the NMR in relation to smoking topography and tested the hypothesis that normal metabolizers have a greater total daily puff volume than slow metabolizers. METHODS: The Pennsylvania Adult Smoking Study (PASS) is a longitudinal study of 352 adults who smoked, on average, 17 cigarettes per day. Subjects used a portable smoking topography device over a two-day period at home and at work. We measured the ratio of 3'hydroxycotinine to cotinine in the saliva of the subjects. RESULTS: In multiple linear regression analyses, a higher rate of nicotine metabolism was significantly associated with increased daily puffs and total daily puff volume. In a mediation analysis, a significant, indirect effect of race on the relationship between NMR and puff volume was observed, with 22% of the effect mediated by white race. A higher NMR was also associated with female gender, white race, cigarettes per day and nicotine dependence measures. CONCLUSION: The NMR was associated with tobacco use patterns including smoking topography. Faster nicotine metabolism was associated with greater total daily puffs and puff volume.
BACKGROUND: The nicotine metabolite ratio (NMR) as measured by the ratio of 3'hydroxycotinine to cotinine has been examined in relation to tobacco use patterns including cigarettes per day and quit success to determine its role in nicotine dependence. We examined the NMR in relation to smoking topography and tested the hypothesis that normal metabolizers have a greater total daily puff volume than slow metabolizers. METHODS: The Pennsylvania Adult Smoking Study (PASS) is a longitudinal study of 352 adults who smoked, on average, 17 cigarettes per day. Subjects used a portable smoking topography device over a two-day period at home and at work. We measured the ratio of 3'hydroxycotinine to cotinine in the saliva of the subjects. RESULTS: In multiple linear regression analyses, a higher rate of nicotine metabolism was significantly associated with increased daily puffs and total daily puff volume. In a mediation analysis, a significant, indirect effect of race on the relationship between NMR and puff volume was observed, with 22% of the effect mediated by white race. A higher NMR was also associated with female gender, white race, cigarettes per day and nicotine dependence measures. CONCLUSION: The NMR was associated with tobacco use patterns including smoking topography. Faster nicotine metabolism was associated with greater total daily puffs and puff volume.
Authors: Yen-Chu Chen; James P Fowler; Jing Wang; Christy J W Watson; Yasmine Sherafat; Andres Staben; Philip Lazarus; Travis T Denton; Christie D Fowler Journal: J Pharmacol Exp Ther Date: 2019-10-18 Impact factor: 4.030
Authors: Charlotte G G M Pauwels; Agnes W Boots; Wouter F Visser; Jeroen L A Pennings; Reinskje Talhout; Frederik-Jan Van Schooten; Antoon Opperhuizen Journal: Int J Environ Res Public Health Date: 2020-05-06 Impact factor: 3.390
Authors: Devan R Romero; Kim Pulvers; Erika Carter; Casey Barber; Nora Satybaldiyeva; Thomas E Novotny; Eyal Oren Journal: Int J Environ Res Public Health Date: 2021-11-12 Impact factor: 3.390
Authors: Andréa L Hobkirk; Vishal Midya; Nicolle M Krebs; Sophia I Allen; Lisa Reinhart; Dongxiao Sun; Andrea L Stennett; Joshua E Muscat Journal: BMC Public Health Date: 2021-05-31 Impact factor: 3.295