| Literature DB >> 29989811 |
Jiao Li1, Hua Tang1, Tibor Kurtán2, Attila Mándi2, Chun-Lin Zhuang1, Li Su1, Gui-Liang Zheng3, Wen Zhang1.
Abstract
Swinhoeisterols C-F (1-4), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A (5). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC50 value of 8.8 μM, whereas compounds 2-4 were not active.Entities:
Mesh：
Substances：
Year: 2018 PMID： 29989811 DOI： 10.1021/acs.jnatprod.8b00281
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050