Literature DB >> 2998965

Modeling of substrate elimination by the liver: has the albumin receptor model superseded the well-stirred model?

D J Morgan, D B Jones, R A Smallwood.   

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Year:  1985        PMID： 2998965     DOI： 10.1002/hep.1840050629

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


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  7 in total

1.  Optimal experimental design for precise estimation of the parameters of the axial dispersion model of hepatic elimination.

Authors:  C H Chou; L Aarons; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1998-10

Review 2.  Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery.

Authors:  D K Meijer; P van der Sluijs
Journal:  Pharm Res       Date:  1989-02       Impact factor: 4.200

3.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

Review 4.  Clinical significance of pharmacokinetic models of hepatic elimination.

Authors:  D J Morgan; R A Smallwood
Journal:  Clin Pharmacokinet       Date:  1990-01       Impact factor: 6.447

5.  At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

Authors:  D Sorrentino; R B Robinson; C L Kiang; P D Berk
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

Review 6.  The influence of binding to albumin and alpha 1-acid glycoprotein on the clearance of drugs by the liver.

Authors:  D K Meijer; P Van der Sluijs
Journal:  Pharm Weekbl Sci       Date:  1987-04-24

7.  Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models.

Authors:  R H Smallwood; D J Morgan; G W Mihaly; D B Jones; R A Smallwood
Journal:  J Pharmacokinet Biopharm       Date:  1988-08
  7 in total

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