Xiao-Mei Zhong1,2, Min Dong2, Fei Wang2, Qinge Zhang3, Gabor S Ungvari4, Chee H Ng5, Helen F K Chiu6, Tian-Mei Si7, Kang Sim8, Ajit Avasthi9, Sandeep Grover9, Mian-Yoon Chong10, Kok-Yoon Chee11, Shigenobu Kanba12, Min-Soo Lee13, Shu-Yu Yang14, Pichet Udomratn15, Roy A Kallivayalil16, Andi J Tanra17, Margarita M Maramis18, Winston W Shen19, Norman Sartorius20, Rathi Mahendran21, Chay-Hoon Tan22, Naotaka Shinfuku23, Yu-Tao Xiang2. 1. Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Hui Hospital), Guangzhou, China. 2. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. 3. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China. 4. The University of Notre Dame Australia / Graylands Hospital, Perth, Victoria, Australia. 5. Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 6. Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China. 7. Peking University Institute of Mental Health (the sixth Hospital) & National Clinical Research Center for Mental Disorders & the key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. 8. Institute of Mental Health, Buangkok View, Buangkok Green Medical Park, Singapore. 9. Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India. 10. Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital-Kaohsiung Medical Center and School of Medicine, Chang Gung University, Taiwan. 11. Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia. 12. Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan. 13. Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea. 14. Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan. 15. Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. 16. Department of Psychiatry, Pushpagiri Institute of Medical Sciences, Thiruvalla, India. 17. Department of Psychiatry, Hasanuddin University Faculty of Medicine, Makassar, Sulawesi Selatan, Indonesia. 18. Dr. Soetomo Hospital - Faculty of Medicine, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia. 19. Departments of Psychiatry, TMU-Wan Fang Medical Center and School of Medicine, Taipei Medical University, Taipei, Taiwan. 20. Association for the Improvement of Mental Health Programmes, Geneva, Switzerland. 21. Departments of Psychological Medicine, National University of Singapore, Singapore. 22. Departments of Pharmacology, National University of Singapore, Singapore. 23. International Center for Medical Research, Kobe University School of Medicine, Kobe, Japan.
Abstract
BACKGROUND: The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatric patients prescribed with antidepressants in Asia. METHODS: Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data. RESULTS: Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR = 1.7, P < 0.001), higher number of depressive symptoms (OR = 1.09, P = 0.016), being treated in psychiatric hospital (OR = 0.5, P = 0.002), living in high income countries/territories (OR = 2.4, P = 0.002), use of benzodiazepines (OR = 1.4, P = 0.013) and diagnosis of 'other psychiatric disorders' (except mood, anxiety disorders and schizophrenia) (OR = 2.7, P < 0.001) were significantly associated with physical comorbidities. CONCLUSIONS: Physical comorbidities in older patients prescribed with antidepressants were common in Asia. Integrating physical care into the treatment of older psychiatric patients should be urgently considered.
BACKGROUND: The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatricpatients prescribed with antidepressants in Asia. METHODS: Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data. RESULTS: Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR = 1.7, P < 0.001), higher number of depressive symptoms (OR = 1.09, P = 0.016), being treated in psychiatric hospital (OR = 0.5, P = 0.002), living in high income countries/territories (OR = 2.4, P = 0.002), use of benzodiazepines (OR = 1.4, P = 0.013) and diagnosis of 'other psychiatric disorders' (except mood, anxiety disorders and schizophrenia) (OR = 2.7, P < 0.001) were significantly associated with physical comorbidities. CONCLUSIONS: Physical comorbidities in older patients prescribed with antidepressants were common in Asia. Integrating physical care into the treatment of older psychiatricpatients should be urgently considered.
Authors: Mary K Lam; Lawrence T Lam; Kerryn Butler-Henderson; Jonathan King; Tahnee Clark; Peta Slocombe; Katherine Dimarco; Wendell Cockshaw Journal: Front Psychiatry Date: 2022-09-09 Impact factor: 5.435