Literature DB >> 29988984

Production of Humanized Mice through Stem Cell Transfer.

Devra D Huey1, Stefan Niewiesk1.   

Abstract

The development of humanized mice has become a prominent tool for translational animal studies of human diseases. Here we show how immune deficient mice can be "humanized" by injections of human umbilical cord stem cells. The engraftment of these cells and development into human lymphocytes has been possible because of the development of novel severely immune deficient mouse strains. Here we present proven protocols for the generation and analysis of humanized mice on the NSG mouse background.

Entities:  

Keywords:  Human Immune System (HIS); Humanized mice; NOD scid gamma (NSG); human umbilical cord stem cells (HUSC)

Mesh：

Year:  2018        PMID： 29988984      PMCID： PMC6034996          DOI： 10.1002/cpmo.38

Source DB:  PubMed          Journal:  Curr Protoc Mouse Biol        ISSN： 2161-2617


  23 in total

1.  Development of a human adaptive immune system in cord blood cell-transplanted mice.

Authors:  Elisabetta Traggiai; Laurie Chicha; Luca Mazzucchelli; Lucio Bronz; Jean-Claude Piffaretti; Antonio Lanzavecchia; Markus G Manz
Journal:  Science       Date:  2004-04-02       Impact factor: 47.728

2.  Opportunistic bacterial infections in breeding colonies of the NSG mouse strain.

Authors:  O Foreman; A M Kavirayani; S M Griffey; R Reader; L D Shultz
Journal:  Vet Pathol       Date:  2010-09-03       Impact factor: 2.221

3.  Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

Authors:  Fumihiko Ishikawa; Masaki Yasukawa; Bonnie Lyons; Shuro Yoshida; Toshihiro Miyamoto; Goichi Yoshimoto; Takeshi Watanabe; Koichi Akashi; Leonard D Shultz; Mine Harada
Journal:  Blood       Date:  2005-05-26       Impact factor: 22.113

4.  Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.

Authors:  Devra D Huey; Brad Bolon; Krista M D La Perle; Priya Kannian; Steven Jacobson; Lee Ratner; Patrick L Green; Stefan Niewiesk
Journal:  Comp Med       Date:  2018-02-01       Impact factor: 0.982

5.  Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.

Authors:  Leonard D Shultz; Yoriko Saito; Yuho Najima; Satoshi Tanaka; Toshiki Ochi; Mariko Tomizawa; Takehiko Doi; Akiko Sone; Nahoko Suzuki; Hiroshi Fujiwara; Masaki Yasukawa; Fumihiko Ishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-06       Impact factor: 11.205

6.  Isolation of highly purified autologous and allogeneic peripheral CD34+ cells using the CliniMACS device.

Authors:  M Schumm; P Lang; G Taylor; S Kuçi; T Klingebiel; H J Bühring; A Geiselhart; D Niethammer; R Handgretinger
Journal:  J Hematother       Date:  1999-04

7.  Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

Authors:  L D Shultz; P A Schweitzer; S W Christianson; B Gott; I B Schweitzer; B Tennent; S McKenna; L Mobraaten; T V Rajan; D L Greiner
Journal:  J Immunol       Date:  1995-01-01       Impact factor: 5.422

8.  Creation of "humanized" mice to study human immunity.

Authors:  Todd Pearson; Dale L Greiner; Leonard D Shultz
Journal:  Curr Protoc Immunol       Date:  2008-05

9.  Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria.

Authors:  Jing Huang; Xiangming Li; Jordana G A Coelho-dos-Reis; Min Zhang; Robert Mitchell; Raquel Tayar Nogueira; Tiffany Tsao; Amy R Noe; Ramses Ayala; Vincent Sahi; Gabriel M Gutierrez; Victor Nussenzweig; James M Wilson; Elizabeth H Nardin; Ruth S Nussenzweig; Moriya Tsuji
Journal:  J Immunol Methods       Date:  2015-09-26       Impact factor: 2.303

10.  HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.

Authors:  Julien Villaudy; Mélanie Wencker; Nicolas Gadot; Nicolas A Gillet; Jean-Yves Scoazec; Louis Gazzolo; Markus G Manz; Charles R M Bangham; Madeleine Duc Dodon
Journal:  PLoS Pathog       Date:  2011-09-01       Impact factor: 6.823
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  8 in total

1.  HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.

Authors:  Jingyu Xiang; Daniel A Rauch; Devra D Huey; Amanda R Panfil; Xiaogang Cheng; Alison K Esser; Xinming Su; John C Harding; Yalin Xu; Gregory C Fox; Francesca Fontana; Takayuki Kobayashi; Junyi Su; Hemalatha Sundaramoorthi; Wing Hing Wong; Yizhen Jia; Thomas J Rosol; Deborah J Veis; Patrick L Green; Stefan Niewiesk; Lee Ratner; Katherine N Weilbaecher
Journal:  JCI Insight       Date:  2019-10-03

2.  Essential Role of Human T Cell Leukemia Virus Type 1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice.

Authors:  Veronica Galli; Christopher C Nixon; Natasa Strbo; Maria Artesi; Maria F de Castro-Amarante; Katherine McKinnon; Dai Fujikawa; Maria Omsland; Robyn Washington-Parks; Laura Romero; Breanna Caruso; Keith Durkin; Sophia Brown; Baktiar Karim; Monica Vaccari; Steve Jacobson; Jerome A Zack; Anne Van den Broeke; Cynthia Pise-Masison; Genoveffa Franchini
Journal:  J Virol       Date:  2019-09-12       Impact factor: 5.103

3.  Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice.

Authors:  Saumi Mathews; Amanda Branch Woods; Ikumi Katano; Edward Makarov; Midhun B Thomas; Howard E Gendelman; Larisa Y Poluektova; Mamoru Ito; Santhi Gorantla
Journal:  Mol Neurodegener       Date:  2019-03-05       Impact factor: 14.195

Review 4.  CRISPR Genome Editing Applied to the Pathogenic Retrovirus HTLV-1.

Authors:  Amanda R Panfil; Patrick L Green; Kristine E Yoder
Journal:  Front Cell Infect Microbiol       Date:  2020-12-23       Impact factor: 5.293

Review 5.  Regulation of HTLV-1 transformation.

Authors:  Kyle J Ernzen; Amanda R Panfil
Journal:  Biosci Rep       Date:  2022-03-31       Impact factor: 3.840

6.  Spinal cord injury causes chronic bone marrow failure.

Authors:  Randall S Carpenter; Jessica M Marbourg; Faith H Brennan; Katherine A Mifflin; Jodie C E Hall; Roselyn R Jiang; Xiaokui M Mo; Malith Karunasiri; Matthew H Burke; Adrienne M Dorrance; Phillip G Popovich
Journal:  Nat Commun       Date:  2020-07-24       Impact factor: 14.919

7.  CRISPR-Cas9 Gene Editing of Hematopoietic Stem Cells from Patients with Friedreich's Ataxia.

Authors:  Celine J Rocca; Joseph N Rainaldi; Jay Sharma; Yanmeng Shi; Joseph H Haquang; Jens Luebeck; Prashant Mali; Stephanie Cherqui
Journal:  Mol Ther Methods Clin Dev       Date:  2020-05-03       Impact factor: 6.698

8.  Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice.

Authors:  Randall S Carpenter; Roselyn R Jiang; Faith H Brennan; Jodie C E Hall; Manoj K Gottipati; Stefan Niewiesk; Phillip G Popovich
Journal:  Sci Rep       Date:  2019-12-13       Impact factor: 4.379
  8 in total

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