Daren Hanumunthadu1, Elon H C Van Dijk2, Sankeert Gangakhedkar3, Abhilash Goud3, Chui Ming Gemmy Cheung4, Daniel Cherfan5, Chintan Sarvaiya6, Alay Banker6, Catherine Meyerle7, Camiel J Boon2, Rishi Singh5, Lihteh Wu8, Jay Chhablani9. 1. Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK. 2. Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands. 3. Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India. 4. Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore. 5. Clevelend Clinic Cole Eye Institute, 2022 E 105th Street, Cleveland, OH, 44106, USA. 6. Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Ahmedabad, 380009, India. 7. Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 8. Apdo 144-1225 Plaza Mayor, San José, 1225, Costa Rica. 9. Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India. jay.chhablani@gmail.com.
Abstract
BACKGROUND: Comparison of presentation and outcomes of central serous chorioretinopathy (CSC) between male and female subjects in different ethnic populations. METHODS: Retrospective comparison between male and female subjects with CSC was completed. Demographic details, clinical presentations, imaging features and treatment outcomes were compared at baseline and at last follow-up. RESULTS: This study included 155 male and 155 female subjects with a mean (CSD) age of 43.8 ± 10.3 and 57.0 ± 12.1 years, respectively, and a mean duration of follow-up of 8.49 ± 12.6 months. At presentation, there was no difference in visual acuity; however, visual acuity was significantly higher for female subjects at last follow-up (p = 0.02). Optical coherence tomography (OCT) analysis showed that subretinal deposits (p < 0.001), hyperreflective foci (p = 0.001), retinal pigment epithelial detachment (p = 0.01) and retinal pigment epithelium (RPE) irregularities (p = 0.03) were higher in male subjects at presentation. Angiographic analysis showed that diffuse leakage and RPE tracts were common in males (p = 0.01 and p = 0.02). No significant differences in choroidal dilatation or diffuse choroidal leakages were noted. CONCLUSIONS: Female subjects with CSC appear to have better outcomes, with less chances of diffuse RPE damage and other OCT features compared to males.
BACKGROUND: Comparison of presentation and outcomes of central serous chorioretinopathy (CSC) between male and female subjects in different ethnic populations. METHODS: Retrospective comparison between male and female subjects with CSC was completed. Demographic details, clinical presentations, imaging features and treatment outcomes were compared at baseline and at last follow-up. RESULTS: This study included 155 male and 155 female subjects with a mean (CSD) age of 43.8 ± 10.3 and 57.0 ± 12.1 years, respectively, and a mean duration of follow-up of 8.49 ± 12.6 months. At presentation, there was no difference in visual acuity; however, visual acuity was significantly higher for female subjects at last follow-up (p = 0.02). Optical coherence tomography (OCT) analysis showed that subretinal deposits (p < 0.001), hyperreflective foci (p = 0.001), retinal pigment epithelial detachment (p = 0.01) and retinal pigment epithelium (RPE) irregularities (p = 0.03) were higher in male subjects at presentation. Angiographic analysis showed that diffuse leakage and RPE tracts were common in males (p = 0.01 and p = 0.02). No significant differences in choroidal dilatation or diffuse choroidal leakages were noted. CONCLUSIONS: Female subjects with CSC appear to have better outcomes, with less chances of diffuse RPE damage and other OCT features compared to males.
Authors: R F Spaide; L Campeas; A Haas; L A Yannuzzi; Y L Fisher; D R Guyer; J S Slakter; J A Sorenson; D A Orlock Journal: Ophthalmology Date: 1996-12 Impact factor: 12.079
Authors: Qi Sheng You; Liang Xu; Hua Yang; Yi Bin Li; Shuang Wang; Jin Da Wang; Jing Shang Zhang; Ya Xing Wang; Jost B Jonas Journal: Ophthalmology Date: 2012-08-24 Impact factor: 12.079
Authors: Praveen J Patel; Paul J Foster; Carlota M Grossi; Pearse A Keane; Fang Ko; Andrew Lotery; Tunde Peto; Charles A Reisman; Nicholas G Strouthidis; Qi Yang Journal: Ophthalmology Date: 2015-12-30 Impact factor: 12.079