| Literature DB >> 29987836 |
Max L Senders1,2, Mark E Lobatto3, Raphael Soler1,4, Olivier Lairez1,5, Carlos Pérez-Medina1, Claudia Calcagno1, Zahi A Fayad1, Willem J M Mulder1,2, Francois Fay6,7.
Abstract
Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit's relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.Entities:
Keywords: Imaging model; New Zealand White rabbit; PET/MRI; Rabbit atherosclerosis model; Translational
Mesh：
Year: 2018 PMID： 29987836 DOI： 10.1007/978-1-4939-8597-5_30
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745