| Literature DB >> 29987145 |
Takeo Yasu1, Takaaki Konuma2, Seiichiro Kuroda1, Satoshi Takahashi3, Arinobu Tojo3.
Abstract
Intravenous voriconazole (VRC) is formulated by the incorporation of sulfobutylether-β-cyclodextrin (SBECD), which may accumulate to adversely affect renal function. However, the effect of long-term use of intravenous VRC on renal function is unclear. Our retrospective analysis of data confirmed that worsening of renal function was significantly associated with a cumulative dose of intravenous VRC (≥400 mg/kg), suggesting that a higher cumulative dose of intravenous VRC is a risk factor for renal dysfunction.Entities:
Keywords: cumulative dose; intravenous; renal function; sulfobutylether-β-cyclodextrin; voriconazole
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Year: 2018 PMID: 29987145 PMCID: PMC6125534 DOI: 10.1128/AAC.00507-18
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191