[The research progress of CPEB4 in tumor].

Cytoplasmic polyadenylation element binding protein 4 (Cytoplasmic polyadenylation element binding protein 4, CPEB4) ,a newly discovered member of the cytoplasmic polyadenylation element binding proteins, is a kind of RNA binding proteins with mediator of mRNA cytoplasmic polyadenylation and translation. CPEB4 plays an important role in the proliferation, migration, invasion and interstitial transformation of many tumors. In recent years, studies have shown that CPEB4 has abnormal expression in a variety of human tumors, and the abnormal expression of cancer patients has a significant correlation with the prognosis. Based on the current research progress, the purpose of this article is to further understand the relationship between CPEB4 and malignant tumor and its molecular mechanism of regulating tumorigenesis and to provide a new direction and means for the molecular diagnosis and targeted therapy of malignant tumor. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.