Mingqiang Li1, Lu Ren1, Yingna Zhang2, Jie Lv2, Hua Fang2, Jing Zhang2, Xue Zhao2, Jiaojiao Han2, Pengwei Huang3, Ying Du4, Qingyong Zhang3, Junhong Yang5, Yunke Zhang5, Feng Gao6. 1. The Second Affiliated Hospital of Zheng-zhou University, Department of Neurology, No. 2 of Jingba Road, Zhengzhou, CN, 450014, China. 2. The Henan Academy of Medical and Pharmacologic Sciences, Department of Neuroimmunology Research, No. 40 of Daxue Road, Zhengzhou, CN, 450052, China. 3. The Second Affiliated Hospital of Zheng-Zhou University, Department of Thoracic Surgery, No. 2 of Jingba Road, Zhengzhou, CN, 450014, China. 4. Basic Medical College, Zhengzhou University, Department of Immunology and Microbiology, No. 100 of Science Road, Zhengzhou, CN, 450001, China. 5. The First Affiliated Hospital of Henan University of TCM, Department of Encephalopathy, No. 19 of People's Road, Zhengzhou, CN, 450008, China. 6. The Henan Academy of Medical and Pharmacologic Sciences, Department of Neuroimmunology Research, No. 40 of Daxue Road, Zhengzhou, CN, 450052, China. Electronic address: gaoyuanshan@126.com.
Abstract
OBJECTIVES: To explore the characteristics of double seropositive myasthenia gravis (DSP-MG). PATIENTS AND METHODS: A literature review of twenty-four cases of DSP-MG including 2 novel cases presented in the current study, was performed. RESULTS: Among 24 reported patients, 7 were male (29.17%) and 17 were female (70.83%). Among 20 patients with known age, the mean age of onset was 37.30 ± 19.50 years, among which the average onset age of the 6 male patients was 53.17 ± 8.98 years, while the average onset age of the remaining 14 female patients was 30.50 ± 18.94 years. Three patients had simple ocular muscle-type MG (14.28%), while 18 (85.71%) had non-ocular muscle-type MG. After administration of penicillide, 1 patient developed DSP-MG. In 9 cases, patients developed DSP-MG after thymectomy, while 5 patients naturally developed DSP-MG. CONCLUSION: Women more frequently developed DSP-MG than men and men were diagnosed at an older age. MG is typically found in the ocular muscles, bulbar and limb muscles.
OBJECTIVES: To explore the characteristics of double seropositive myasthenia gravis (DSP-MG). PATIENTS AND METHODS: A literature review of twenty-four cases of DSP-MG including 2 novel cases presented in the current study, was performed. RESULTS: Among 24 reported patients, 7 were male (29.17%) and 17 were female (70.83%). Among 20 patients with known age, the mean age of onset was 37.30 ± 19.50 years, among which the average onset age of the 6 male patients was 53.17 ± 8.98 years, while the average onset age of the remaining 14 female patients was 30.50 ± 18.94 years. Three patients had simple ocular muscle-type MG (14.28%), while 18 (85.71%) had non-ocular muscle-type MG. After administration of penicillide, 1 patient developed DSP-MG. In 9 cases, patients developed DSP-MG after thymectomy, while 5 patients naturally developed DSP-MG. CONCLUSION:Women more frequently developed DSP-MG than men and men were diagnosed at an older age. MG is typically found in the ocular muscles, bulbar and limb muscles.