Kyoung Min Kim1, Soo Lim1, Tae Jung Oh1, Jae Hoon Moon1, Sung Hee Choi1, Jae Young Lim2, Ki Woong Kim3,4, Kyong Soo Park5, Hak Chul Jang1. 1. Department of Internal Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea. 2. Department of Rehabilitation Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea. 3. Department of Neuropsychiatry, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea. 4. Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Korea. 5. Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Korea.
Abstract
Background: The aims of this study were to investigate the longitudinal changes in muscle and bone with aging, and to clarify the muscle-bone relationships. Methods: In a community-based prospective study, a total of 172 men and 165 women aged ≥ 65 years who had performed body composition analysis and bone mineral density (BMD) by dual-energy x-ray absorptiometry at baseline and 5-year follow-up evaluations were included. Results: The rate of BMD loss in total hip was significantly associated with baseline legs lean mass and loss rate of leg strength, but not with the rate of muscle mass losses in men (r = .205 in leg lean mass, r = .170 in loss rate of leg muscle strength, p < .05 respectively). However, in women, it was significantly correlated with the rate of leg lean mass loss, but not with baseline values, and the rate of loss in leg muscle strength (r = .169 in the rate of loss in leg lean mass, r = .246 in the rate of loss in leg muscle strength, p < .05 respectively). In multivariate analyses, the rates of decrease in leg muscle strength showed independent positive associations with loss in total hip BMD in both men and women (β = 0.023 for men and β = 0.045 for women, both p < .05 respectively). Conclusion: There was a gender difference in muscle and bone mass changes with aging, and muscle-bone interactions as well. However, a longitudinal change in muscle strength was the most significant independent factor associated with bone loss for both genders.
Background: The aims of this study were to investigate the longitudinal changes in muscle and bone with aging, and to clarify the muscle-bone relationships. Methods: In a community-based prospective study, a total of 172 men and 165 women aged ≥ 65 years who had performed body composition analysis and bone mineral density (BMD) by dual-energy x-ray absorptiometry at baseline and 5-year follow-up evaluations were included. Results: The rate of BMD loss in total hip was significantly associated with baseline legs lean mass and loss rate of leg strength, but not with the rate of muscle mass losses in men (r = .205 in leg lean mass, r = .170 in loss rate of leg muscle strength, p < .05 respectively). However, in women, it was significantly correlated with the rate of leg lean mass loss, but not with baseline values, and the rate of loss in leg muscle strength (r = .169 in the rate of loss in leg lean mass, r = .246 in the rate of loss in leg muscle strength, p < .05 respectively). In multivariate analyses, the rates of decrease in leg muscle strength showed independent positive associations with loss in total hip BMD in both men and women (β = 0.023 for men and β = 0.045 for women, both p < .05 respectively). Conclusion: There was a gender difference in muscle and bone mass changes with aging, and muscle-bone interactions as well. However, a longitudinal change in muscle strength was the most significant independent factor associated with bone loss for both genders.
Authors: Robinson Ramírez-Vélez; Mikel Izquierdo; Antonio García-Hermoso; Leidy T Ordoñez-Mora; Carlos Cano-Gutierrez; Florelba Campo-Lucumí; Miguel Ángel Pérez-Sousa Journal: Sci Rep Date: 2022-07-12 Impact factor: 4.996
Authors: A Elhakeem; A Hartley; Y Luo; A L Goertzen; K Hannam; E M Clark; W D Leslie; J H Tobias Journal: Osteoporos Int Date: 2018-12-14 Impact factor: 4.507
Authors: Tuuli H Suominen; Johanna Edgren; Anu Salpakoski; Mauri Kallinen; Tomas Cervinka; Timo Rantalainen; Timo Törmäkangas; Ari Heinonen; Sarianna Sipilä Journal: BMC Musculoskelet Disord Date: 2020-06-09 Impact factor: 2.362