Guihua Tang1, Wen Yin2, Youde Cao1, Liming Tan1, Shuyu Wu2, Yudong Cao2, Xianyong Fu2, Jing Yan3, Xingjun Jiang2. 1. a Department of Clinical Laboratory , Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University) , Changsha , Hunan Province , China. 2. b Department of Neurosurgery , Xiangya Hospital of Central South University , Changsha , Hunan Province , China. 3. c Department of Ultrasound , Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University) , Changsha , Hunan Province , China.
Abstract
BACKGROUND: The emergence of vaccine-associated paralytic poliomyelitis has become an ongoing burden of poliomyelitis. During this special period from OPV to IPV-only immunization schedule, we did a meta-analysis to compare the immunogenicity of sequential IPV and OPV versus IPV alone in healthy infants. METHODS: This systematic review and meta-analysis was registered at international prospective register of systematic reviews (PROSPERO), and the number was CRD42017054889. We performed it as described. RESULTS: Finally, 6 articles were qualified for our review. The results showed that seroconversion rates against all 3 serotype polioviruses were non-inferior and Geometric mean antibody titers (GMTs) were superior in sequential schedules compared with IPV-only schedule. Thus, the sequential vaccination schedules could induce a stronger immunogenicity. CONCLUSIONS: To decrease vaccine-associated and vaccine-derived poliomyelitis, it is a reasonable option to select sequential schedules during this special transition from OPV to IPV-only immunization schedule, which coincides with the current WHO recommendations.
BACKGROUND: The emergence of vaccine-associated paralytic poliomyelitis has become an ongoing burden of poliomyelitis. During this special period from OPV to IPV-only immunization schedule, we did a meta-analysis to compare the immunogenicity of sequential IPV and OPV versus IPV alone in healthy infants. METHODS: This systematic review and meta-analysis was registered at international prospective register of systematic reviews (PROSPERO), and the number was CRD42017054889. We performed it as described. RESULTS: Finally, 6 articles were qualified for our review. The results showed that seroconversion rates against all 3 serotype polioviruses were non-inferior and Geometric mean antibody titers (GMTs) were superior in sequential schedules compared with IPV-only schedule. Thus, the sequential vaccination schedules could induce a stronger immunogenicity. CONCLUSIONS: To decrease vaccine-associated and vaccine-derived poliomyelitis, it is a reasonable option to select sequential schedules during this special transition from OPV to IPV-only immunization schedule, which coincides with the current WHO recommendations.
Authors: R W Sutter; A J Suleiman; P G Malankar; F R Mehta; M A Medany; M A Arif; R W Linkins; M A Pallansch; M S El-Bualy; S E Robertson Journal: J Infect Dis Date: 1997-02 Impact factor: 5.226
Authors: Edwin J Asturias; Ananda S Bandyopadhyay; Steve Self; Luis Rivera; Xavier Saez-Llorens; Eduardo Lopez; Mario Melgar; James T Gaensbauer; William C Weldon; M Steven Oberste; Bhavesh R Borate; Chris Gast; Ralf Clemens; Walter Orenstein; Miguel O'Ryan G; José Jimeno; Sue Ann Costa Clemens; Joel Ward; Ricardo Rüttimann Journal: Lancet Date: 2016-05-19 Impact factor: 79.321