Thymus-derived lymphocytes in the Vogt-Koyanagi-Harada syndrome.

Previous investigations have suggested that immunologic factors may play a role in the Vogt-Koyanagi-Harada syndrome, a disease involving the eye, central nervous system, and dermis. Among patients with this disease we have observed a decrease in their peripheral blood lymphocytes, as measured by two types of rosette assays. These results strengthen the concept that an altered immunologic status may be important in the pathophysiology of this disease.