Literature DB >> 29984799

Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis.

D Passali1, G C Passali2, L M Bellussi1, C Sarafoleanu3, M Loglisci1, C Manea3, C Iosif4, F M Passali5.   

Abstract

SUMMARY: The aim of this research is to investigate penetration of Bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS) versus a control group. Bromelain is derived from pineapple (Ananas comosus) and has various pharmacological effects. 40 patients (20 patients and 20 controls) were enrolled in the study. Bromelain 500 mg tablet twice daily was administered for 30 days. We scored bromelain presence in turbinate and ethmoid mucosas and in the serum of both the groups. Bromelain has an excellent distribution from blood to rhinosinusal mucosa. Its diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies.
Copyright © 2018 Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy.

Entities:  

Keywords:  Bromelain; Chronic rhinosinusitis; Immunohistochemistry

Mesh：

Substances：

Year:  2018        PMID： 29984799      PMCID： PMC6036946          DOI： 10.14639/0392-100X-1693

Source DB:  PubMed          Journal:  Acta Otorhinolaryngol Ital        ISSN： 0392-100X            Impact factor:   2.124


  15 in total

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Journal:  Eur J Med Res       Date:  2005-08-17       Impact factor: 2.175

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6.  Prognostic and predictive significance of the bcl-2/IgH translocation in malignant follicular lymphomas.

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Journal:  Ear Nose Throat J       Date:  1997-12       Impact factor: 1.697

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Authors:  T L Mynott; S Guandalini; F Raimondi; A Fasano
Journal:  Gastroenterology       Date:  1997-07       Impact factor: 22.682

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Authors:  Rajendra Pavan; Sapna Jain; Ajay Kumar
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  3 in total

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Journal:  Biomedicines       Date:  2022-06-17

2.  The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis.

Authors:  C N Tiboc Schnell; Gabriela Adriana Filip; N Decea; R Moldovan; R Opris; S C Man; B Moldovan; L David; F Tabaran; D Olteanu; A M Gheldiu; I Baldea
Journal:  Inflammopharmacology       Date:  2021-04-21       Impact factor: 4.473

Review 3.  Beneficial Properties of Bromelain.

Authors:  Pawel Hikisz; Joanna Bernasinska-Slomczewska
Journal:  Nutrients       Date:  2021-11-29       Impact factor: 5.717
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