Literature DB >> 2998380

Direct stimulation by thyrotropin-releasing hormone (TRH) of polyphosphoinositide hydrolysis in GH3 cell membranes by a guanine nucleotide-modulated mechanism.

D O Lucas, S M Bajjalieh, J A Kowalchyk, T F Martin.   

Abstract

Polyphosphoinositide hydrolysis was examined in membranes from thyrotropin-releasing hormone (TRH)-responsive GH3 pituitary cells. [3H]Inositol phosphates (IP2 and IP3) were generated upon incubation of membranes from [3H]inositol-labeled cells indicating the presence of a membrane-associated polyphosphoinositide phosphodiesterase (PPI PDE). Membrane PPI PDE activity was found to be stimulated by TRH and by GTP-gamma-S in Ca2+-modulated manner. In addition, TRH-stimulated PPI hydrolysis was potentiated by GTP. These results demonstrate direct in vitro effects of a hormone on PPI turnover and suggest the involvement of a GTP-binding component in transmembrane signalling by TRH.

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Year:  1985        PMID： 2998380     DOI： 10.1016/0006-291x(85)91192-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

1.  Inositol 1,4,5-trisphosphate binds to a specific receptor and releases microsomal calcium in the anterior pituitary gland.

Authors:  G Guillemette; T Balla; A J Baukal; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

2.  Activation of phospholipase C associated with isolated rabbit platelet membranes by guanosine 5'-[gamma-thio]triphosphate and by thrombin in the presence of GTP.

Authors:  J K Hrbolich; M Culty; R J Haslam
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

3.  Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity.

Authors:  I Litosch
Journal:  Biochem J       Date:  1987-05-15       Impact factor: 3.857

4.  Phospholipase C-beta 1 is regulated by a pertussis toxin-insensitive G-protein.

Authors:  T F Martin; J E Lewis; J A Kowalchyk
Journal:  Biochem J       Date:  1991-12-15       Impact factor: 3.857

Review 5.  Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?

Authors:  R Ravindra
Journal:  Endocrine       Date:  1997-10       Impact factor: 3.633

6.  Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.

Authors:  S Cockcroft; J A Taylor
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

7.  The dependence on Ca2+ of the guanine-nucleotide-activated polyphosphoinositide phosphodiesterase in neutrophil plasma membranes.

Authors:  S Cockcroft
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

8.  Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

Authors:  M Matsuoka; H Itoh; T Kozasa; Y Kaziro
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

Review 9.  Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay.

Authors:  N N Osborne; A B Tobin; H Ghazi
Journal:  Neurochem Res       Date:  1988-03       Impact factor: 3.996

10.  Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C.

Authors:  E G Lapetina; B R Reep
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205
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