Literature DB >> 29982883

Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications.

Akanksha Agrawal1, Geetha Suryakumar1, Richa Rathor2.   

Abstract

The misbehaving attitude of Ca2+ signaling pathways could be the probable reason in many muscular disorders such as myopathies, systemic disorders like hypoxia, sepsis, cachexia, sarcopenia, heart failure, and dystrophy. The present review throws light upon the calcium flux regulating signaling channels like ryanodine receptor complex (RyR1), SERCA (Sarco-endoplasmic Reticulum Calcium ATPase), DHPR (Dihydropyridine Receptor) or Cav1.1 and Na+/Ca2+ exchange pump in detail and how remodelling of these channels contribute towards disturbed calcium homeostasis. Understanding these pathways will further provide an insight for establishing new therapeutic approaches for the prevention and treatment of muscle atrophy under stress conditions, targeting calcium ion channels and associated regulatory proteins.

Entities:  

Keywords:  Atrophy; Calcium; Muscle; RyR1; Ryanodine receptor

Year:  2018        PMID： 29982883      PMCID： PMC6235775          DOI： 10.1007/s12079-018-0477-z

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  144 in total

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6.  Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.

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Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-04       Impact factor: 11.205

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Journal:  Cell Death Differ       Date:  2015-06-19       Impact factor: 15.828
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  14 in total

1.  Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum Ca2+ homeostasis in skeletal muscles.

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Journal:  Antiviral Res       Date:  2021-01-13       Impact factor: 5.970

2.  The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.

Authors:  Mehdi Pirouz; Chih-Hao Wang; Qi Liu; Aref G Ebrahimi; Farnaz Shamsi; Yu-Hua Tseng; Richard I Gregory
Journal:  Nat Commun       Date:  2020-05-26       Impact factor: 14.919

3.  Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention.

Authors:  Ya-Jyun Liang; I-Hsuan Yang; Yi-Wen Lin; Jhih-Ni Lin; Chang-Chin Wu; Chih-Yung Chiang; Kun-Hung Lai; Feng-Huei Lin
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4.  Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.

Authors:  Gourav Bhardwaj; Christie M Penniman; Katherine Klaus; Eric T Weatherford; Hui Pan; Jonathan M Dreyfuss; K Sreekumaran Nair; C Ronald Kahn; Brian T O'Neill
Journal:  Front Physiol       Date:  2022-02-04       Impact factor: 4.566

5.  Human pancreatic tumour organoid-derived factors enhance myogenic differentiation.

Authors:  Rianne D W Vaes; David P J van Dijk; Elham Aïda Farshadi; Steven W M Olde Damink; Sander S Rensen; Ramon C Langen
Journal:  J Cachexia Sarcopenia Muscle       Date:  2022-02-11       Impact factor: 12.910

Review 6.  Calcium Signaling in Vertebrate Development and Its Role in Disease.

Authors:  Sudip Paudel; Regan Sindelar; Margaret Saha
Journal:  Int J Mol Sci       Date:  2018-10-30       Impact factor: 5.923

Review 7.  Growth Hormone Secretagogues and the Regulation of Calcium Signaling in Muscle.

Authors:  Elena Bresciani; Laura Rizzi; Silvia Coco; Laura Molteni; Ramona Meanti; Vittorio Locatelli; Antonio Torsello
Journal:  Int J Mol Sci       Date:  2019-09-05       Impact factor: 5.923

8.  CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade.

Authors:  Suting Li; Menglei Hao; Bingshu Li; Mao Chen; Jue Chen; Jianming Tang; Shasha Hong; Jie Min; Ming Hu; Li Hong
Journal:  Cell Death Dis       Date:  2020-04-24       Impact factor: 8.469

Review 9.  Pharmacogenetics of Statin-Induced Myotoxicity.

Authors:  Ping Siu Kee; Paul Ken Leong Chin; Martin A Kennedy; Simran D S Maggo
Journal:  Front Genet       Date:  2020-10-16       Impact factor: 4.599

10.  To Synthesize Hydroxyapatite by Modified Low Temperature Method Loaded with Bletilla striata Polysaccharide as Antioxidant for the Prevention of Sarcopenia by Intramuscular Administration.

Authors:  Ya-Jyun Liang; Jia-Yu Hong; I-Hsuan Yang; Xin-Ran Zhou; Yi-Wen Lin; Tzu-Chieh Lin; Chun-Han Hou; Feng-Huei Lin
Journal:  Antioxidants (Basel)       Date:  2021-03-20
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