Literature DB >> 29982253

Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

Roger van Groenendael1,2,3,4, Matthijs Kox1,2, Lucas T van Eijk1,2,3,4, Peter Pickkers1,2.   

Abstract

The systemic inflammatory response following infectious or non-infectious insults is related to morbidity (including acute kidney injury) and mortality. Pregnancy is associated with immunotolerance and an increased glomerular filtration rate. EA-230, a linear tetrapeptide (Alanine-Glutamine-Glycine-Valine), derived from the β-chain of the human chorionic gonadotropin hormone, has shown immunomodulatory and renoprotective properties in several pre-clinical animal models of systemic inflammation. Furthermore, an excellent safety profile of EA-230 was observed in phase 1 studies in humans, and the immunomodulatory effects of EA-230 were recently demonstrated in a phase IIa study during human experimental endotoxemia. A prospective double-blind placebo-controlled randomized trial in 180 patients undergoing elective CABG-surgery with or without valve surgery is currently conducted to investigate the immunomodulatory and renoprotective properties of EA-230.
© 2018 The Author(s) Published by S. Karger AG, Basel.

Entities:  

Keywords:  Cytokines; Immunomodulation; Inflammation; Pregnancy; Renal

Mesh：

Substances：

Year:  2018        PMID： 29982253      PMCID： PMC6214607          DOI： 10.1159/000490772

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   2.847


  14 in total

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Journal:  J Am Soc Nephrol       Date:  2015-04-08       Impact factor: 10.121

2.  Mitigation of septic shock in mice and rhesus monkeys by human chorionic gonadotrophin-related oligopeptides.

Authors:  N A Khan; M P M Vierboom; C van Holten-Neelen; E Breedveld; E Zuiderwijk-Sick; A Khan; I Kondova; G Braskamp; H F J Savelkoul; W A Dik; B A 't Hart; R Benner
Journal:  Clin Exp Immunol       Date:  2010-03-16       Impact factor: 4.330

Review 3.  Manifestations of chronic disease during pregnancy.

Authors:  Risto J Kaaja; Ian A Greer
Journal:  JAMA       Date:  2005-12-07       Impact factor: 56.272

4.  Sepsis in European intensive care units: results of the SOAP study.

Authors:  Jean-Louis Vincent; Yasser Sakr; Charles L Sprung; V Marco Ranieri; Konrad Reinhart; Herwig Gerlach; Rui Moreno; Jean Carlet; Jean-Roger Le Gall; Didier Payen
Journal:  Crit Care Med       Date:  2006-02       Impact factor: 7.598

5.  Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study.

Authors:  Eric A J Hoste; Sean M Bagshaw; Rinaldo Bellomo; Cynthia M Cely; Roos Colman; Dinna N Cruz; Kyriakos Edipidis; Lui G Forni; Charles D Gomersall; Deepak Govil; Patrick M Honoré; Olivier Joannes-Boyau; Michael Joannidis; Anna-Maija Korhonen; Athina Lavrentieva; Ravindra L Mehta; Paul Palevsky; Eric Roessler; Claudio Ronco; Shigehiko Uchino; Jorge A Vazquez; Erick Vidal Andrade; Steve Webb; John A Kellum
Journal:  Intensive Care Med       Date:  2015-07-11       Impact factor: 17.440

6.  Amelioration of renal ischaemia-reperfusion injury by synthetic oligopeptides related to human chorionic gonadotropin.

Authors:  Nisar A Khan; Denis Susa; Jan Willem van den Berg; Martin Huisman; Miriam H Ameling; Sandra van den Engel; Henk P Roest; Jan N M Ijzermans; Willem A Dik; Robbert Benner; Ron W F de Bruin
Journal:  Nephrol Dial Transplant       Date:  2009-07-25       Impact factor: 5.992

7.  Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype.

Authors:  Hui Wan; Marjan A Versnel; Lonneke M E Leijten; Cornelia G van Helden-Meeuwsen; Durk Fekkes; Pieter J M Leenen; Nisar A Khan; Robbert Benner; Rebecca C M Kiekens
Journal:  J Leukoc Biol       Date:  2008-01-02       Impact factor: 4.962

8.  Synthetic oligopeptides related to the [beta]-subunit of human chorionic gonadotropin attenuate inflammation and liver damage after (trauma) hemorrhagic shock and resuscitation.

Authors:  H Rogier van den Berg; Nisar A Khan; Marten van der Zee; Fred Bonthuis; Jan N M IJzermans; Willem A Dik; Ron W F de Bruin; Robbert Benner
Journal:  Shock       Date:  2009-03       Impact factor: 3.454

9.  A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype.

Authors:  Didier Payen; Anne-Claire Lukaszewicz; Matthieu Legrand; Etienne Gayat; Valérie Faivre; Bruno Megarbane; Elie Azoulay; Fabienne Fieux; Dominique Charron; Pascale Loiseau; Marc Busson
Journal:  PLoS One       Date:  2012-06-06       Impact factor: 3.240

10.  Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol?

Authors:  Pierre Delanaye; Natalie Ebert; Toralf Melsom; Flavio Gaspari; Christophe Mariat; Etienne Cavalier; Jonas Björk; Anders Christensson; Ulf Nyman; Esteban Porrini; Giuseppe Remuzzi; Piero Ruggenenti; Elke Schaeffner; Inga Soveri; Gunnar Sterner; Bjørn Odvar Eriksen; Sten-Erik Bäck
Journal:  Clin Kidney J       Date:  2016-08-23
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Review 1.  Antimicrobial Peptides Controlling Resistant Bacteria in Animal Production.

Authors:  Gisele Rodrigues; Lucas Souza Santos; Octávio Luiz Franco
Journal:  Front Microbiol       Date:  2022-05-19       Impact factor: 6.064

2.  Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study.

Authors:  Roger van Groenendael; Remi Beunders; Pleun Hemelaar; Jan Hofland; Wim J Morshuis; Johannes G van der Hoeven; Jelle Gerretsen; Gert Wensvoort; Emma J Kooistra; Wout J Claassen; Denise Waanders; Maud G A Lamberts; Leonie S E Buijsse; Matthijs Kox; Lucas T van Eijk; Peter Pickkers
Journal:  Crit Care Med       Date:  2021-05-01       Impact factor: 9.296
  2 in total

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