| Literature DB >> 29981397 |
Meigeng Hu1, Yihang Li2, Zhaocui Sun1, Xiaowei Huo3, Nailiang Zhu1, Zhonghao Sun1, Yangyang Liu1, Haifeng Wu1, Xudong Xu1, Guoxu Ma4, Guang Li2.
Abstract
Nine new polyoxypregnane glycosides, obcordatas A-I (1-9), were isolated from Aspidopterys obcordata Hemsl vines. Their structures were elucidated by extensive spectroscopic methods. Separated compounds were evaluated for antitumor activities against the human cancer cell lines AGS, SW480, HuH-7 and MCF-7, and compounds 1-6 and 9 showed selective cytotoxicity against HuH-7 cells with IC50 values of 8.7, 10.2, 7.5, 12.1, 16.5, 14.3, and 17.4 μM, respectively. Flow cytometry experiments showed that the effects of compound 1 on the cell cycle were attributable to cell cycle arrest at G1/S phase.Entities:
Keywords: Aspidopterys obcordata; cytotoxic activity; polyoxypregnane glycosides
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Year: 2018 PMID： 29981397 DOI： 10.1016/j.fitote.2018.07.003
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882