Emily K Plowman1,2,3, Lauren Tabor-Gray1, K Michelle Rosado1, Terrie Vasilopoulos4, Raele Robison1, Jennifer L Chapin1, Joy Gaziano5, Tuan Vu6, Clifton Gooch6. 1. Swallowing Systems Core, University of Florida, Gainesville, Florida, USA. 2. Department of Speech, Language and Hearing Sciences, College of Public Health and Health Professions, University of Florida, P.O. Box 117420, Gainesville, Florida, 32610, USA. 3. Department of Neurology, University of Florida, Gainesville, Florida, USA. 4. Department of Anesthesiology, University of Florida, Gainesville, Florida, USA. 5. Joy McCann Culverhouse Center for Swallowing Disorders, University of South Florida, Tampa, Florida, USA. 6. Department of Neurology, University of South Florida, Tampa, Florida, USA.
Abstract
INTRODUCTION: The purpose of this study was to determine the impact of an in-home expiratory muscle strength training (EMST) program on pulmonary, swallow, and cough function in individuals with amyotrophic lateral sclerosis (ALS). METHODS:EMST was tested in a prospective, single-center, double-blind, randomized, controlled trial of 48 ALS individuals who completed 8 weeks of eitheractive EMST (n = 24) orsham EMST (n = 24). The primary outcome to assess treatment efficacy was change in maximum expiratory pressure (MEP). Secondary outcomes included: cough spirometry; swallowing; forced vital capacity; and scoring on the ALS Functional Rating Scale-Revised. RESULTS: Treatment was well tolerated with 96% of patients completing the protocol. Significant differences in group change scores were noted for MEP and Dynamic Imaging Grade of Swallowing Toxicity scores (P < 0.02). No differences were noted for other secondary measures. DISCUSSION: This respiratory training program was well-tolerated and led to improvements in respiratory and bulbar function in ALS. Muscle Nerve 59:40-46, 2019.
RCT Entities:
INTRODUCTION: The purpose of this study was to determine the impact of an in-home expiratory muscle strength training (EMST) program on pulmonary, swallow, and cough function in individuals with amyotrophic lateral sclerosis (ALS). METHODS: EMST was tested in a prospective, single-center, double-blind, randomized, controlled trial of 48 ALS individuals who completed 8 weeks of either active EMST (n = 24) or sham EMST (n = 24). The primary outcome to assess treatment efficacy was change in maximum expiratory pressure (MEP). Secondary outcomes included: cough spirometry; swallowing; forced vital capacity; and scoring on the ALS Functional Rating Scale-Revised. RESULTS: Treatment was well tolerated with 96% of patients completing the protocol. Significant differences in group change scores were noted for MEP and Dynamic Imaging Grade of Swallowing Toxicity scores (P < 0.02). No differences were noted for other secondary measures. DISCUSSION: This respiratory training program was well-tolerated and led to improvements in respiratory and bulbar function in ALS. Muscle Nerve 59:40-46, 2019.
Authors: Lauren Tabor Gray; Kasey L McElheny; Terrie Vasilopoulos; James Wymer; Barbara K Smith; Emily K Plowman Journal: Dysphagia Date: 2022-08-05 Impact factor: 2.733
Authors: Cara Donohue; Yassin Khalifa; Shitong Mao; Subashan Perera; Ervin Sejdić; James L Coyle Journal: J Speech Lang Hear Res Date: 2021-08-24 Impact factor: 2.297
Authors: Lawren VandeVrede; Peter A Ljubenkov; Julio C Rojas; Ariane E Welch; Adam L Boxer Journal: Neurotherapeutics Date: 2020-10 Impact factor: 7.620