Jennifer Tinklenberg1,2, Margaret Beatka1,2, James L W Bain3, Emily M Siebers1,2, Hui Meng1,2, R Scott Pearsall4, Michael W Lawlor1,2, Danny A Riley3. 1. Division of Pediatric Pathology, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. 2. Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. 3. Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. 4. Acceleron Pharma Inc, Cambridge, Massachusetts, USA.
Abstract
INTRODUCTION: Difficulty in modeling congenital contractures (deformities of muscle-tendon unit development that include shortened muscles and lengthened tendons) has limited research of new treatments. METHODS: Early immobilization of the ankle in prepuberal mice was used to produce deformities similar to congenital contractures. Stretch treatment, electrostimulation, and local intramuscular injection of a follistatin analog (FST-288) were assessed as therapeutic interventions for these deformities. RESULTS: Ankle immobilization at full plantarflexion and 90 ° created tendon lengthening and muscle shortening in the tibialis anterior and soleus. Stretch treatment produced minimal evidence for longitudinal muscle growth and electrostimulation provided no additional benefit. Stretch treatment with FST-288 produced greater longitudinal muscle growth and less tendon lengthening, constituting the best treatment response. DISCUSSION: Ankle immobilization recapitulates key morphologic features of congenital contracture, and these features can be mitigated by a combination of stretch and pharmacological approaches that may be useful in patients. Muscle Nerve 58: 718-725, 2018.
INTRODUCTION: Difficulty in modeling congenital contractures (deformities of muscle-tendon unit development that include shortened muscles and lengthened tendons) has limited research of new treatments. METHODS: Early immobilization of the ankle in prepuberal mice was used to produce deformities similar to congenital contractures. Stretch treatment, electrostimulation, and local intramuscular injection of a follistatin analog (FST-288) were assessed as therapeutic interventions for these deformities. RESULTS: Ankle immobilization at full plantarflexion and 90 ° created tendon lengthening and muscle shortening in the tibialis anterior and soleus. Stretch treatment produced minimal evidence for longitudinal muscle growth and electrostimulation provided no additional benefit. Stretch treatment with FST-288 produced greater longitudinal muscle growth and less tendon lengthening, constituting the best treatment response. DISCUSSION: Ankle immobilization recapitulates key morphologic features of congenital contracture, and these features can be mitigated by a combination of stretch and pharmacological approaches that may be useful in patients. Muscle Nerve 58: 718-725, 2018.
Authors: Lisa A Harvey; Owen M Katalinic; Robert D Herbert; Anne M Moseley; Natasha A Lannin; Karl Schurr Journal: Cochrane Database Syst Rev Date: 2017-01-09
Authors: Catherine E Winbanks; Kate L Weeks; Rachel E Thomson; Patricio V Sepulveda; Claudia Beyer; Hongwei Qian; Justin L Chen; James M Allen; Graeme I Lancaster; Mark A Febbraio; Craig A Harrison; Julie R McMullen; Jeffrey S Chamberlain; Paul Gregorevic Journal: J Cell Biol Date: 2012-06-18 Impact factor: 10.539
Authors: William P Mayer; Josemberg da S Baptista; Flavia De Oliveira; Matsuyoshi Mori; Edson A Liberti Journal: Histochem Cell Biol Date: 2021-09-02 Impact factor: 4.304
Authors: Glen H Nuckolls; Kathi Kinnett; Sudarshan Dayanidhi; Andrea A Domenighetti; Tina Duong; Yetrib Hathout; Michael W Lawlor; Sabrina S M Lee; S Peter Magnusson; Craig M McDonald; Elizabeth M McNally; Natalie F Miller; Bradley B Olwin; Preeti Raghavan; Thomas J Roberts; Seward B Rutkove; John F Sarwark; Claudia R Senesac; Leslie F Vogel; Glenn A Walter; Rebecca J Willcocks; William Z Rymer; Richard L Lieber Journal: Muscle Nerve Date: 2020-03-07 Impact factor: 3.852