Samuel Sarrazin1,2,3,4, Arnaud Cachia5,6,7, Franz Hozer4,8,9, Colm McDonald10, Louise Emsell11,12, Dara M Cannon10, Michele Wessa13, Julia Linke13, Amelia Versace14, Nora Hamdani1,2,3, Marc-Antoine D'Albis1,2,3,4, Marine Delavest15, Mary L Phillips14, Paolo Brambilla16, Marcella Bellani17, Mircea Polosan18, Pauline Favre4, Marion Leboyer1,2,3,19, Jean-François Mangin20, Josselin Houenou1,2,3,4,19. 1. APHP, DHU PePSY, Pôle de psychiatrie et d'addictologie des Hôpitaux Universitaires Henri Mondor, Créteil, France. 2. INSERM U955, Team 15, "Translationnal Psychiatry", IMRB, Créteil, France. 3. Fondation FondaMental, Créteil, France. 4. Lab. UNIACT, NeuroSpin, CEA, Gif-sur-Yvette, France. 5. Imaging Biomarkers for Brain Development and Disorders, UMR INSERM 894, Université Paris Descartes, Paris, France. 6. Laboratoire de Psychologie du Développement et de l'Éducation de l'enfant (LaPsyDÉ), UMR CNRS 8240, Université Paris Descartes, Paris, France. 7. Institut Universitaire de France, Paris, France. 8. Assistance Publique-Hôpitaux de Paris (AP-HP), Corentin-Celton Hospital, Department of Psychiatry, Issy-les-Moulineaux, France. 9. Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France. 10. Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland. 11. Old Age Psychiatry, University Psychiatric Centre (UPC)-KU Leuven, Leuven, Belgium. 12. Translational MRI & Radiology, KU Leuven, Leuven, Belgium. 13. Department of Neuropsychology and Clinical Psychology, Psychological Institute, Johannes-Gutenberg University of Mainz, Mainz, Germany. 14. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA. 15. APHP, Service de Psychiatrie, Hôpital Lariboisiere Fernand Widal, INSERM U 705 CNRS UMR 8206, Paris Diderot University, Paris, France. 16. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. 17. Section of Psychiatry, AOUI Verona/Department of Neurosciences, Biomedicine and Movement Sciences/University of Verona, Verona, Italy. 18. Université Grenoble Alpes, Inserm U1216 Grenoble Institute of Neuroscience, CHU Grenoble Alpes, Grenoble, France. 19. Faculté de Médecine, Université Paris Est, Créteil, France. 20. Lab. UNATI, NeuroSpin, CEA, Gif-sur-Yvette, France.
Abstract
OBJECTIVES: Brain sulcation is an indirect marker of neurodevelopmental processes. Studies of the cortical sulcation in bipolar disorder have yielded mixed results, probably due to high variability in clinical phenotype. We investigated whole-brain cortical sulcation in a large sample of selected patients with high neurodevelopmental load. METHODS: A total of 263 patients with bipolar disorder I and 320 controls were included in a multicentric magnetic resonance imaging (MRI) study. All subjects underwent high-resolution T1-weighted brain MRI. Images were processed with an automatized pipeline to extract the global sulcal index (g-SI) and the local sulcal indices (l-SIs) from 12 a priori determined brain regions covering the whole brain. We compared l-SI and g-SI between patients with and without early-onset bipolar disorder and between patients with and without a positive history of psychosis, adjusting for age, gender and handedness. RESULTS: Patients with early-onset bipolar disorder had a higher l-SI in the right prefrontal dorsolateral region. Patients with psychotic bipolar disorder had a decreased l-SI in the left superior parietal cortex. No group differences in g-SI or l-SI were found between healthy subjects and the whole patient cohort. We could replicate the early-onset finding in an independent cohort. CONCLUSIONS: Our work suggests that bipolar disorder is not associated with generalized abnormalities of sulcation, but rather with localized changes of cortical folding restricted to patients with a heavy neurodevelopmental loading. These findings support the hypothesis that bipolar disorder is heterogeneous but may be disentangled using MRI, and suggest the need for investigations into neurodevelopmental deviations in the disorder.
OBJECTIVES: Brain sulcation is an indirect marker of neurodevelopmental processes. Studies of the cortical sulcation in bipolar disorder have yielded mixed results, probably due to high variability in clinical phenotype. We investigated whole-brain cortical sulcation in a large sample of selected patients with high neurodevelopmental load. METHODS: A total of 263 patients with bipolar disorder I and 320 controls were included in a multicentric magnetic resonance imaging (MRI) study. All subjects underwent high-resolution T1-weighted brain MRI. Images were processed with an automatized pipeline to extract the global sulcal index (g-SI) and the local sulcal indices (l-SIs) from 12 a priori determined brain regions covering the whole brain. We compared l-SI and g-SI between patients with and without early-onset bipolar disorder and between patients with and without a positive history of psychosis, adjusting for age, gender and handedness. RESULTS:Patients with early-onset bipolar disorder had a higher l-SI in the right prefrontal dorsolateral region. Patients with psychotic bipolar disorder had a decreased l-SI in the left superior parietal cortex. No group differences in g-SI or l-SI were found between healthy subjects and the whole patient cohort. We could replicate the early-onset finding in an independent cohort. CONCLUSIONS: Our work suggests that bipolar disorder is not associated with generalized abnormalities of sulcation, but rather with localized changes of cortical folding restricted to patients with a heavy neurodevelopmental loading. These findings support the hypothesis that bipolar disorder is heterogeneous but may be disentangled using MRI, and suggest the need for investigations into neurodevelopmental deviations in the disorder.
Authors: Gaelle E Doucet; Dongdong Lin; Yuhui Du; Zening Fu; David C Glahn; Vincent D Calhoun; Jessica Turner; Sophia Frangou Journal: NPJ Schizophr Date: 2020-12-04
Authors: Jack T Whiteley; Sarah Fernandes; Amandeep Sharma; Ana Paula D Mendes; Vipula Racha; Simone K Benassi; Maria C Marchetto Journal: Stem Cell Reports Date: 2022-01-20 Impact factor: 7.294