| Literature DB >> 29981156 |
Yuko Horio1, Koutaro Takamatsu2, Daisuke Tamanoi1, Ryo Sato1, Koichi Saruwatari1, Tokunori Ikeda2,3, Shunya Nakane2,4, Makoto Nakajima2, Sho Saeki1, Hidenori Ichiyasu1, Kazuhiko Fujii1, Yusuke Tomita1.
Abstract
PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-γ and Th1 cytokine production. In turn, IFN-γ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.Entities:
Keywords: Immune checkpoint blockade; Immune-related adverse event; Lung cancer; Tissue factor; Trousseau's syndrome
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Year: 2018 PMID: 29981156 DOI: 10.1002/eji.201847645
Source DB: PubMed Journal: Eur J Immunol ISSN: 0014-2980 Impact factor: 5.532