Maria Waizel1,2,3, Margarita G Todorova4,5, Celine Terrada6, Phuc LeHoang6, Natalie Massamba6, Bahram Bodaghi6. 1. Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, CH-4031, Basel, Switzerland. maria.waizel@usb.ch. 2. University of Basel, Basel, Switzerland. maria.waizel@usb.ch. 3. DHU Vision and Handicaps, Pierre and Marie Curie School of Medicine, Sorbonne Universités, Paris, France. maria.waizel@usb.ch. 4. Department of Ophthalmology, University Hospital Basel, Mittlere Strasse 91, CH-4031, Basel, Switzerland. 5. University of Basel, Basel, Switzerland. 6. DHU Vision and Handicaps, Pierre and Marie Curie School of Medicine, Sorbonne Universités, Paris, France.
Abstract
PURPOSE: To compare the superficial (FAZ-S) and deep foveal avascular zones (FAZ-D) of non-infectious anterior and posterior uveitis to healthy controls, using optical coherence tomography angiography (OCTA). METHODS: OCTA was performed on 74 eyes: 34 eyes with non-infectious posterior uveitis (with (post+CME) and without macular edema (post-CME)), 11 eyes with non-infectious anterior uveitis (with (ant+CME) and without macular edema (ant-CME)), and the control group which included 29 healthy eyes. RESULTS: Eyes suffering from non-infectious posterior uveitis presented with significantly larger FAZ-D when compared to healthy controls, both in the presence or in the absence of macular edema (p < 0.001). In the presence of macular edema, eyes presenting with anterior uveitis (ant+CME) also showed significantly larger FAZ-S (p = 0.03) and FAZ-D (p < 0.001), when compared to healthy controls. In the absence of macular edema, eyes with anterior uveitis cannot be distinguished from controls (p > 0.6). CONCLUSION: The deep retinal foveal avascular zone seems to be enlarged in eyes presenting with non-infectious posterior uveitis, both in the presence or absence of macular edema.
PURPOSE: To compare the superficial (FAZ-S) and deep foveal avascular zones (FAZ-D) of non-infectious anterior and posterior uveitis to healthy controls, using optical coherence tomography angiography (OCTA). METHODS: OCTA was performed on 74 eyes: 34 eyes with non-infectious posterior uveitis (with (post+CME) and without macular edema (post-CME)), 11 eyes with non-infectious anterior uveitis (with (ant+CME) and without macular edema (ant-CME)), and the control group which included 29 healthy eyes. RESULTS: Eyes suffering from non-infectious posterior uveitis presented with significantly larger FAZ-D when compared to healthy controls, both in the presence or in the absence of macular edema (p < 0.001). In the presence of macular edema, eyes presenting with anterior uveitis (ant+CME) also showed significantly larger FAZ-S (p = 0.03) and FAZ-D (p < 0.001), when compared to healthy controls. In the absence of macular edema, eyes with anterior uveitis cannot be distinguished from controls (p > 0.6). CONCLUSION: The deep retinal foveal avascular zone seems to be enlarged in eyes presenting with non-infectious posterior uveitis, both in the presence or absence of macular edema.
Authors: Francesco Pichi; Sunil K Srvivastava; Saradha Chexal; Andrea Lembo; Luiz H Lima; Piergiorgio Neri; Andrea Saitta; Jay Chhablani; Thomas A Albini; Paolo Nucci; K Bailey Freund; Hyewon Chung; Careen Y Lowder; David Sarraf Journal: Retina Date: 2016-12 Impact factor: 4.256
Authors: Alessio Cerquaglia; Marco Lupidi; Tito Fiore; Barbara Iaccheri; Paolo Perri; Carlo Cagini Journal: Int Ophthalmol Date: 2016-09-02 Impact factor: 2.031
Authors: Sarwar Zahid; Kevin C Chen; Jesse J Jung; Chandrakumar Balaratnasingam; Quraish Ghadiali; John Sorenson; Soraya Rofagha; K Bailey Freund; Lawrence A Yannuzzi Journal: Retina Date: 2017-08 Impact factor: 4.256
Authors: Ashleigh L Levison; Kimberly M Baynes; Careen Y Lowder; Peter K Kaiser; Sunil K Srivastava Journal: Br J Ophthalmol Date: 2016-08-18 Impact factor: 4.638
Authors: Alice Y Kim; Damien C Rodger; Anoush Shahidzadeh; Zhongdi Chu; Nicole Koulisis; Bruce Burkemper; Xuejuan Jiang; Kathryn L Pepple; Ruikang K Wang; Carmen A Puliafito; Narsing A Rao; Amir H Kashani Journal: Am J Ophthalmol Date: 2016-09-02 Impact factor: 5.258
Authors: Francesco Pichi; David Sarraf; Sruthi Arepalli; Careen Y Lowder; Emmett T Cunningham; Piergiorgio Neri; Thomas A Albini; Vishali Gupta; Kimberly Baynes; Sunil K Srivastava Journal: Prog Retin Eye Res Date: 2017-04-29 Impact factor: 21.198
Authors: Michael Karampelas; Dawn A Sim; Colin Chu; Ester Carreno; Pearse A Keane; Javier Zarranz-Ventura; Mark Westcott; Richard W J Lee; Carlos E Pavesio Journal: Am J Ophthalmol Date: 2015-02-21 Impact factor: 5.258
Authors: Margarita G Todorova; Hendrik P N Scholl; Maria Della Volpe Waizel Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-09-10 Impact factor: 3.117
Authors: Vita L S Dingerkus; Marion R Munk; Max P Brinkmann; Florentina J Freiberg; Florian M A Heussen; Stephan Kinzl; Sandra Lortz; Selim Orgül; Matthias Becker Journal: J Ophthalmic Inflamm Infect Date: 2019-05-28